Wake slow waves in focal human epilepsy impact network activity and cognition.
Wake slow waves in focal human epilepsy impact network activity and cognition.
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DOI：
10.1038/s41467-023-42971-3
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发表时间：
2023-11-30
影响因子：
16.6
通讯作者：
Walker, Matthew C.
中科院分区：
文献类型：
--
作者：
Sheybani, Laurent;Vivekananda, Umesh;Rodionov, Roman;Diehl, Beate;Chowdhury, Fahmida A.;McEvoy, Andrew W.;Miserocchi, Anna;Bisby, James A.;Bush, Daniel;Burgess, Neil;Walker, Matthew C.
神经元活动的慢波是睡眠的基本组成部分，被认为具有稳态和恢复功能。尽管如此，它们与病理学的相互作用尚不清楚，只有间接证据表明它们在清醒时存在。使用25例癫痫患者颞叶的皮质内记录，我们证明了存在局部唤醒慢波（LoWS）与睡眠慢波的关键特征，包括神经元放电的下降状态。与神经元活动减少一致，LoWS与认知处理减慢有关。然而，我们还发现，低WS显示出与发作间期癫痫样放电（IED）的稳态关系的签名：在IED之前网络兴奋性的建立过程中表现出渐进的适应，并减少后续IED对网络兴奋性的影响。因此，我们提出了一个癫痫稳态假说：癫痫的慢波减少异常活动的代价是短暂的认知障碍。睡眠中的慢波对大脑功能的稳态调节至关重要。在这里，作者表明癫痫患者在清醒期间发生类似的慢波活动，以抵消异常癫痫大脑活动的影响。
Slow waves of neuronal activity are a fundamental component of sleep that are proposed to have homeostatic and restorative functions. Despite this, their interaction with pathology is unclear and there is only indirect evidence of their presence during wakefulness. Using intracortical recordings from the temporal lobe of 25 patients with epilepsy, we demonstrate the existence of local wake slow waves (LoWS) with key features of sleep slow waves, including a down-state of neuronal firing. Consistent with a reduction in neuronal activity, LoWS were associated with slowed cognitive processing. However, we also found that LoWS showed signatures of a homeostatic relationship with interictal epileptiform discharges (IEDs): exhibiting progressive adaptation during the build-up of network excitability before an IED and reducing the impact of subsequent IEDs on network excitability. We therefore propose an epilepsy homeostasis hypothesis: that slow waves in epilepsy reduce aberrant activity at the price of transient cognitive impairment. Slow waves in sleep are crucial for homeostatic regulation of brain function. Here the authors show similar slow wave activity occurs during wakefulness in people with epilepsy to counter the impact of abnormal, epileptic, brain activity.
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影响因子：
19.9
作者：
Herweg NA;Solomon EA;Kahana MJ
通讯作者：
Kahana MJ
DOI：
10.1073/pnas.89.10.4363
发表时间：
1992-05-15
影响因子：
11.1
作者：
DUDEK, SM;BEAR, MF
通讯作者：
BEAR, MF
影响因子：
5.6
作者：
Horak PC;Meisenhelter S;Song Y;Testorf ME;Kahana MJ;Viles WD;Bujarski KA;Connolly AC;Robbins AA;Sperling MR;Sharan AD;Worrell GA;Miller LR;Gross RE;Davis KA;Roberts DW;Lega B;Sheth SA;Zaghloul KA;Stein JM;Das SR;Rizzuto DS;Jobst BC
通讯作者：
Jobst BC
影响因子：
14.5
作者：
Frauscher, Birgit;von Ellenrieder, Nicolas;Gotman, Jean
通讯作者：
Gotman, Jean
影响因子：
9.8
作者：
Boran, Ece;Fedele, Tommaso;Sarnthein, Johannes
通讯作者：
Sarnthein, Johannes