Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6.
Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6.
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荟萃分析证实LCE3C_LCE3B缺失是几个族裔牛皮癣的危险因素，并发现与HLA-CW6的相互作用。
DOI：
10.1038/jid.2010.350
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发表时间：
2011-05
期刊：
影响因子：
--
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中科院分区：
文献类型：
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对9389例银屑病患者和9477例对照者的数据进行了多中心荟萃分析，以研究参与皮肤屏障防御的基因LCE 3C和LCE 3B缺失对不同人群银屑病易感性的贡献。该研究证实，LCE 3C和LCE 3B缺失是欧洲人群中银屑病易感性的常见遗传因素[OROverall = 1.21（1.15-1.27）]，并首次直接证明了该缺失与银屑病的相关性[中国人OR = 1.27蒙古族OR = 2.08（1.44-2.99）]。对HLA-Cw 6基因座的分析显示，至少在一些欧洲人群中，LCE 3C和LCE 3B缺失的上位相互作用存在显着差异，表明这两种导致银屑病的主要遗传因素之间存在上位效应。该研究强调了在多个人群中检查遗传风险因素以确定遗传相互作用的价值，并指出需要进一步研究以了解皮肤屏障和免疫系统在银屑病易感性中的相互作用。
A multicenter meta-analysis including data from 9389 psoriasis patients and 9477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in European populations [OROverall = 1.21 (1.15–1.27)], and for the first time directly demonstrated the deletion's association with psoriasis in [Chinese OR = 1.27 (1.16–1.34); Mongolian OR = 2.08 (1.44–2.99)] populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis.
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