Changes in HDL cholesterol, particles, and function associate with pediatric COVID-19 severity.
Changes in HDL cholesterol, particles, and function associate with pediatric COVID-19 severity.
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DOI：
10.3389/fcvm.2022.1033660
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发表时间：
2022
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
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作者：
除了动脉粥样硬化保护之外，高密度脂蛋白 (HDL) 的多种作用还包括与成人 2019 冠状病毒病 (COVID-19) 严重程度有关的免疫功能。我们探讨了青少年中高密度脂蛋白 (HDL) 与 COVID-19 严重程度之间是否存在关联。确定了一个儿科队列 (N = 102)，该队列的 COVID-19 检测结果呈阳性，其疾病表现包括轻微症状或无症状、急性严重症状、儿童多系统炎症综合征 (MIS-C)。从医疗记录中收集临床数据，并通过 NMR 波谱评估储备血浆等份的脂蛋白，并测定 HDL 功能性胆固醇流出能力 (CEC)。根据 COVID-19 状态和症状严重程度对研究结果进行比较。与 30 名门诊 COVID 阴性儿童的脂蛋白、NMR 波谱和 CEC 数据进行比较。 HDL 胆固醇 (HDL-c)、载脂蛋白 AI (ApoA-I)、总 HDL 颗粒、大 HDL 颗粒和小 HDL 颗粒以及 HDL CEC 的降低与 COVID-19 症状严重程度的增加呈现出强烈且直接的线性剂量反应关系。症状轻微或无症状的青少年与未感染者非常相似。脂蛋白 Z (LP-Z) 是一种在严重肝脏炎症时产生的非典型脂蛋白，在 COVID-19 阴性对照中不存在，但在感染最严重和 HDL 参数最低的年轻人中更常见。 HDL CEC 与症状严重程度和 ApoA-I 之间的关系在多重调整模型中仍然显着，该模型还纳入了年龄、种族/族裔、LP-Z 和 GlycA（一种反映多种急性期蛋白的复合生物标志物）的存在。 HDL 参数，尤其是 HDL 功能，可能有助于识别面临 COVID-19 和其他新型传染性病原体更严重后果风险的青少年。
Myriad roles for high-density lipoprotein (HDL) beyond atheroprotection include immunologic functions implicated in the severity of coronavirus disease-2019 (COVID-19) in adults. We explored whether there is an association between HDL and COVID-19 severity in youth. A pediatric cohort (N = 102), who tested positive for COVID-19 across a range of disease manifestations from mild or no symptoms, to acute severe symptoms, to the multisystem inflammatory syndrome of children (MIS-C) was identified. Clinical data were collected from the medical record and reserve plasma aliquots were assessed for lipoproteins by NMR spectroscopy and assayed for HDL functional cholesterol efflux capacity (CEC). Findings were compared by COVID-19 status and symptom severity. Lipoprotein, NMR spectroscopy and CEC data were compared with 30 outpatient COVID negative children. Decreasing HDL cholesterol (HDL-c), apolipoprotein AI (ApoA-I), total, large and small HDL particles and HDL CEC showed a strong and direct linear dose-response relationship with increasing severity of COVID-19 symptoms. Youth with mild or no symptoms closely resembled the uninfected. An atypical lipoprotein that arises in the presence of severe hepatic inflammation, lipoprotein Z (LP-Z), was absent in COVID-19 negative controls but identified more often in youth with the most severe infections and the lowest HDL parameters. The relationship between HDL CEC and symptom severity and ApoA-I remained significant in a multiply adjusted model that also incorporated age, race/ethnicity, the presence of LP-Z and of GlycA, a composite biomarker reflecting multiple acute phase proteins. HDL parameters, especially HDL function, may help identify youth at risk of more severe consequences of COVID-19 and other novel infectious pathogens.
影响因子：
3.9
作者：
van den Berg EH;Flores-Guerrero JL;Gruppen EG;Garcia E;Connelly MA;de Meijer VE;Bakker SJL;Blokzijl H;Dullaart RPF
通讯作者：
Dullaart RPF