DMSOP-cleaving enzymes are diverse and widely distributed in marine microorganisms.
DMSOP-cleaving enzymes are diverse and widely distributed in marine microorganisms.
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DOI：
10.1038/s41564-023-01526-4
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发表时间：
2023-12
影响因子：
28.3
通讯作者：
中科院分区：
文献类型：
--
作者：
丙酸二甲基亚砜 (DMSOP) 是最近发现的一种丰富的海洋有机硫化合物，在氧化应激保护、全球碳和硫循环中发挥作用，如图所示，还可能具有渗透压耐受性。微生物 DMSOP 裂解产生二甲亚砜（一种普遍存在的海洋代谢物）和丙烯酸酯，但负责的酶及其对环境的重要性尚不清楚。在这里，我们报告了以前未知的多种异养细菌、真菌和光养藻类中的 DMSOP 裂解机制，并强调了这一过程在海洋沉积物环境中未被认识到的重要性。这些不同的生物体，包括 Roseobacter、SAR11 细菌和 Emiliania Huxleyi，利用其二甲基磺酰基丙酸裂解酶“Ddd”或“Alma”通过与二甲基磺基丙酸类似的催化机制来裂解 DMSOP。鉴于 DMSOP 产量的年度太克预测及其在海洋沉积物中的普遍性，我们的结果强调 DMSOP 裂解可能是影响碳和硫通量以及生态相互作用的全球重要过程。在最丰富的海洋细菌、藻类和真菌中，二甲基磺基丙酸裂解酶对硫化合物 DMSOP 的循环是多种多样的，并且在地球的海洋和沉积物中普遍存在，可能会影响气候活跃气体的产生。
Dimethylsulfoxonium propionate (DMSOP) is a recently identified and abundant marine organosulfur compound with roles in oxidative stress protection, global carbon and sulfur cycling and, as shown here, potentially in osmotolerance. Microbial DMSOP cleavage yields dimethyl sulfoxide, a ubiquitous marine metabolite, and acrylate, but the enzymes responsible, and their environmental importance, were unknown. Here we report DMSOP cleavage mechanisms in diverse heterotrophic bacteria, fungi and phototrophic algae not previously known to have this activity, and highlight the unappreciated importance of this process in marine sediment environments. These diverse organisms, including Roseobacter, SAR11 bacteria and Emiliania huxleyi, utilized their dimethylsulfoniopropionate lyase ‘Ddd’ or ‘Alma’ enzymes to cleave DMSOP via similar catalytic mechanisms to those for dimethylsulfoniopropionate. Given the annual teragram predictions for DMSOP production and its prevalence in marine sediments, our results highlight that DMSOP cleavage is likely a globally significant process influencing carbon and sulfur fluxes and ecological interactions. Cycling of the sulfur compound DMSOP by dimethylsulfoniopropionate lyase enzymes in the most abundant marine bacteria, algae and fungi is diverse and prevalent in Earth’s oceans and sediments and probably impacts climate-active gas production.
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影响因子：
3.7
作者：
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通讯作者：
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影响因子：
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通讯作者：
Giovannoni, Stephen J.
影响因子：
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作者：
Asher, E. C.;Dacey, J. W. H.;Tortell, P. D.
通讯作者：
Tortell, P. D.