Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy.
Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy.
复制标题
通过植物化学物质靶向癌症干细胞和信号通路：乳腺癌治疗的新方法。
DOI：
10.1016/j.semcancer.2016.09.001
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发表时间：
2016-10
影响因子：
14.5
通讯作者：
Anant S
中科院分区：
文献类型：
--
作者：
Dandawate PR;Subramaniam D;Jensen RA;Anant S
乳腺癌是全球女性中诊断出的最常见的癌症形式，也是美国癌症相关死亡的第二大原因。尽管发展了新的诊断方法，选择性以及靶向化疗及其组合，手术，激素治疗，放射治疗，乳腺癌复发，转移和耐药性仍然是乳腺癌的主要问题。新出现的证据表明存在癌症干细胞（CSC），这是一群具有自我更新，分化以及能够启动和维持肿瘤生长的细胞。此外，CSC被认为是癌症复发、抗癌药物抗性和转移的原因。因此，靶向乳腺CSC的化合物可能是治疗乳腺癌和控制复发和转移的更好的治疗剂。天然存在的化合物，主要是植物化学物质，由于其广泛的安全性、靶向异质癌细胞群体以及CSC的能力以及其关键信号传导途径，近年来获得了极大的关注。因此，在本综述中，我们总结了我们目前对乳腺CSCs及其信号通路的了解，以及影响这些细胞的植物化学物质，包括姜黄素，白藜芦醇，茶多酚（表没食子儿茶素-3-没食子酸酯，表没食子儿茶素），萝卜硫素，染料木黄酮，吲哚-3-甲醇，3，3′-二吲哚基甲烷，维生素E，视黄酸，槲皮素，小白菊素，雷公藤内酯醇，6-姜烯酚，紫檀芪，异甘草素、雷公藤红素和koenimbin。这些植物化学物质可能作为乳腺癌治疗的新的治疗剂和未来的药物开发的领导者。
Breast cancer is the most common form of cancer diagnosed in women worldwide and the second leading cause of cancer-related deaths in the USA. Despite the development of newer diagnostic methods, selective as well as targeted chemotherapies and their combinations, surgery, hormonal therapy, radiotherapy, breast cancer recurrence, metastasis and drug resistance are still the major problems for breast cancer. Emerging evidence suggest the existence of cancer stem cells (CSCs), a population of cells with the capacity to self-renew, differentiate and be capable of initiating and sustaining tumor growth. In addition, CSCs are believed to be responsible for cancer recurrence, anticancer drug resistance, and metastasis. Hence, compounds targeting breast CSCs may be better therapeutic agents for treating breast cancer and control recurrence and metastasis. Naturally occurring compounds, mainly phytochemicals have gained immense attention in recent times because of their wide safety profile, ability to target heterogeneous populations of cancer cells as well as CSCs, and their key signaling pathways. Therefore, in the present review article, we summarize our current understanding of breast CSCs and their signaling pathways, and the phytochemicals that affect these cells including curcumin, resveratrol, tea polyphenols (epigallocatechin-3-gallate, epigallocatechin), sulforaphane, genistein, indole-3-carbinol, 3, 3′-di-indolylmethane, vitamin E, retinoic acid, quercetin, parthenolide, triptolide, 6-shogaol, pterostilbene, isoliquiritigenin, celastrol, and koenimbin. These phytochemicals may serve as novel therapeutic agents for breast cancer treatment and future leads for drug development.
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影响因子：
3.5
作者：
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通讯作者：
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