Working memory updating in individuals with bipolar and unipolar depression: fMRI study.
Working memory updating in individuals with bipolar and unipolar depression: fMRI study.
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DOI：
10.1038/s41398-022-02211-6
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发表时间：
2022-10-11
影响因子：
6.8
通讯作者：
Phillips, Mary L.
中科院分区：
文献类型：
--
作者：
Manelis, Anna;Halchenko, Yaroslav O.;Bonar, Lisa;Stiffler, Richelle S.;Satz, Skye;Miceli, Rachel;Ladouceur, Cecile D.;Bebko, Genna;Iyengar, Satish;Swartz, Holly A.;Phillips, Mary L.
理解不同精神疾病中认知功能障碍的神经生物学特征仍然具有挑战性。在这个次要数据分析中，我们研究了双相情感障碍（BD）、单相抑郁症（UD）和健康对照（HC）个体在工作记忆更新过程中大脑反应的神经生物学差异。个体之间的18-45岁的BD（n = 100），UD（n = 109），HC（n = 172）使用功能磁共振成像扫描，同时执行0回（容易）和2回（困难）的任务，字母作为刺激和快乐，恐惧，或中性的面孔作为干扰。2（n-back）× 3（groups）× 3（distractors）ANCOVA检查了任务期间的反应时（RT），准确性和大脑激活。HC比BD和UD个体表现出更准确和更快的反应。在前额叶，后顶叶，旁扣带皮质，纹状体，枕叶外侧，楔前叶和丘脑区域的困难相关激活组间不同。与UD相比，BD患者的左侧枕叶和右侧扣带旁皮质的难度相关激活差异显著较低。在BD患者中，难度相关的准确性恶化与右侧楔前叶的活动变化较小相关，而难度相关的RT减慢与前额叶、额盖、扣带回旁、后顶叶和枕叶外侧皮质的活动变化较小相关。当前抑郁和躁狂的测量与两组中困难相关的大脑激活差异无关。我们的研究结果表明，工作记忆回路的改变可能是情绪障碍患者工作记忆容量降低的一个特征。左侧枕叶和扣带回旁皮质的异常激活模式可能是BD特有的。
Understanding neurobiological characteristics of cognitive dysfunction in distinct psychiatric disorders remains challenging. In this secondary data analysis, we examined neurobiological differences in brain response during working memory updating among individuals with bipolar disorder (BD), those with unipolar depression (UD), and healthy controls (HC). Individuals between 18–45 years of age with BD (n = 100), UD (n = 109), and HC (n = 172) were scanned using fMRI while performing 0-back (easy) and 2-back (difficult) tasks with letters as the stimuli and happy, fearful, or neutral faces as distractors. The 2(n-back) × 3(groups) × 3(distractors) ANCOVA examined reaction time (RT), accuracy, and brain activation during the task. HC showed more accurate and faster responses than individuals with BD and UD. Difficulty-related activation in the prefrontal, posterior parietal, paracingulate cortices, striatal, lateral occipital, precuneus, and thalamic regions differed among groups. Individuals with BD showed significantly lower difficulty-related activation differences in the left lateral occipital and the right paracingulate cortices than those with UD. In individuals with BD, greater difficulty-related worsening in accuracy was associated with smaller activity changes in the right precuneus, while greater difficulty-related slowing in RT was associated with smaller activity changes in the prefrontal, frontal opercular, paracingulate, posterior parietal, and lateral occipital cortices. Measures of current depression and mania did not correlate with the difficulty-related brain activation differences in either group. Our findings suggest that the alterations in the working memory circuitry may be a trait characteristic of reduced working memory capacity in mood disorders. Aberrant patterns of activation in the left lateral occipital and paracingulate cortices may be specific to BD.
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影响因子：
5.4
作者：
Adler, CM;Holland, SK;Strakowski, SM
通讯作者：
Strakowski, SM
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.
影响因子：
3.7
作者：
Esteban, Oscar;Birman, Daniel;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI