Low-density lipoprotein sub-fraction profiles in obese children before and after attending a residential weight loss intervention.
Low-density lipoprotein sub-fraction profiles in obese children before and after attending a residential weight loss intervention.
复制标题
肥胖儿童参加住院减肥干预前后的低密度脂蛋白亚组分概况。
DOI：
10.5551/jat.e490
复制
发表时间：
2008
影响因子：
4.4
通讯作者：
P. Gately
中科院分区：
文献类型：
--
作者：
R. King;J. Hobkirk;C. Cooke;D. Radley;P. Gately
目的
小而致密的LDL颗粒与冠心病风险增加相关，并且在肥胖相关的血脂异常中普遍存在。这项研究评估了9名儿童（BMI 33.4 +/- 8.4 kg.m（-2），年龄15.1 +/- 2.9岁）体重减轻对LDL峰值颗粒大小和特定LDL亚组分中胆固醇浓度的影响。
方法
每个孩子都进行了有趣的体育活动，饮食限制和修改和生活方式教育课程的住宅夏季减肥干预。在干预前后抽取血液，并通过超离心法测量LDL异质性。
结果
体重的平均变化为-6.8 +/- 4.9 kg，BMI单位为-2.5 +/- 1.4 kg.m（-2），腰围为-6.3 +/- 6.3 cm（均p < 0.01）。绝对LDL-c浓度从106.2 mg/dL降至88.3 mg/dL（p < 0.01）。小密度LDL亚组分（LDL-c III）中所含的胆固醇从54.1 mg/dL降低至40.4 mg/dL（p < 0.01）。颗粒峰值密度从1.041g/mL下降到1.035g/mL（p < 0.01）。在干预前，50.9%的绝对胆固醇在LDL-c III颗粒范围内，变为46.2%。
结论
平均体重减轻-6.8 +/- 4.9 kg降低了绝对LDL-c和胆固醇，特别是LDL-c III颗粒内的胆固醇。LDL峰值颗粒大小增加，并发生一定程度的LDL颗粒重塑。这些有利的适应，在4周内累积，可能与CHD风险降低有关。
AIM
Small dense LDL particles are associated with an increased risk of coronary heart disease and are prevalent in obesity related dyslipidaemia. This study evaluated the effect of weight loss in nine children (BMI 33.4 +/- 8.4 kg.m(-2) and age 15.1 +/- 2.9 years) on LDL peak particle size, and cholesterol concentrations within particular LDL sub-fractions.
METHODS
Each child undertook fun based physical activity, dietary restriction and modification and lifestyle education classes in a residential summer weight loss intervention. Blood was drawn before and after intervention and LDL heterogeneity measured by ultracentrifugation.
RESULTS
The mean change in body weight were -6.8 +/- 4.9 kg, BMI units -2.5 +/- 1.4 kg.m(-2), and waist circumference -6.3 +/- 6.3 cm (all p < 0.01). Absolute LDL-c concentration reduced from 106.2 mg/dL to 88.3 mg/dL (p < 0.01). The cholesterol contained within the small dense LDL sub-fraction (LDL-c III) reduced from 54.1 mg/dL to 40.4 mg/dL (p < 0.01). Peak particle density decreased from 1.041g/mL to 1.035g/mL (p < 0.01). At pre intervention 50.9% of absolute cholesterol was within LDL-c III particles, changing to 46.2%.
CONCLUSION
Mean weight loss of -6.8 +/- 4.9 kg lowers absolute LDL-c and the cholesterol specifically within LDL-c III particles. LDL peak particle size increased and a degree of LDL particle remodelling occurred. These favourable adaptations, accrued in a matter of 4 weeks, maybe associated with a reduction in CHD risk.
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影响因子：
2.8
作者：
BERENSON, GS;WATTIGNEY, WA;STRONG, JP
通讯作者：
STRONG, JP
影响因子：
15.9
作者：
REAVEN, GM;CHEN, YDI;KRAUSS, RM
通讯作者：
KRAUSS, RM
DOI：
10.1001/jama.1996.03540110029028
发表时间：
1996-09
期刊：
JAMA
影响因子：
--
作者：
C. Gardner;S. Fortmann;R. Krauss
通讯作者：
C. Gardner;S. Fortmann;R. Krauss
影响因子：
4.1
作者：
Dempster,P;Aitkens,S
通讯作者：
Aitkens,S