Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth.
Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth.
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DOI：
10.1371/journal.pone.0251803
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Mukhopadhyay A
中科院分区：
文献类型：
--
作者：
Shivakumar N;Sivadas A;Devi S;Jahoor F;McLaughlin J;Smith CP;Kurpad AV;Mukhopadhyay A
肠道微生物群被认为是儿童生长的调节剂。在这里，基于16 S rRNA测序的18-24个月大的印度儿童的粪便微生物群分布进行了评估（n = 41），与他们的人体测量参数，肠道通透性，身体组成和总能量消耗。进行途径分析以评估与发育迟缓、体重不足和消瘦相关的微生物功能。粪便微生物群富含普雷沃氏菌9、双歧杆菌和土氏志贺菌。体重、年龄别体重Z分数（WAZ）和身长别体重Z分数（WLZ），沿着年龄一起，作为微生物群变化的协变量，特别是在男孩中（n = 23）。长双歧杆菌长亚种丰度与WAZ呈正相关，而两歧双歧杆菌和短双歧杆菌丰度与年龄呈负相关。脂多糖生物合成途径在发育不良（n = 16）和消瘦（n = 8）儿童中上调。这项研究的结果表明，儿童性别可能是肠道微生物群对儿童生长作用的关键调节剂。
Gut microbiota has been implicated as a modifier of childhood growth. Here, 16S rRNA sequencing-based fecal microbiota profiles of 18–24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expenditure. Pathway analyses were conducted to assess microbial functions related to stunting, underweight and wasting. The fecal microbiota was enriched in Prevotella 9, Bifidobacterium and Escherichia-Shigella. Weight, weight-for-age Z-scores (WAZ) and weight-for-length Z-scores (WLZ), along with age, acted as covariates of microbiota variation specifically in boys (n = 23). Bifidobacterium longum subsp longum abundance was positively associated with WAZ while Bifidobacterium bifidum and Bifidobacterium breve abundances were negatively associated with age. The lipopolysaccharide biosynthesis pathway was upregulated in stunted (n = 16) and wasted (n = 8) children. Findings from this study indicate that child sex may be a critical modifier of the role of gut microbiota on childhood growth.
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影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
11.1
作者：
Amadi B;Besa E;Zyambo K;Kaonga P;Louis-Auguste J;Chandwe K;Tarr PI;Denno DM;Nataro JP;Faubion W;Sailer A;Yeruva S;Brantner T;Murray J;Prendergast AJ;Turner JR;Kelly P
通讯作者：
Kelly P
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
11.8
作者：
Keusch, Gerald T.;Denno, Donna M.;Brewer, Thomas
通讯作者：
Brewer, Thomas
影响因子：
13.6
作者：
Korpe PS;Petri WA Jr
通讯作者：
Petri WA Jr