β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche.
β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche.
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DOI：
10.1126/science.1248373
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发表时间：
2014-03-21
期刊：
影响因子：
--
通讯作者：
Greco V
中科院分区：
文献类型：
--
作者：
Deschene ER;Myung P;Rompolas P;Zito G;Sun TY;Taketo MM;Saotome I;Greco V
Wnt/β-连环蛋白信号转导通路对组织再生至关重要。然而，目前尚不清楚β-Catenin如何控制干细胞行为以协调有组织的生长。使用实时成像，我们证明了在小鼠毛囊干细胞中特异性地激活β-连环蛋白通过定向细胞分裂和细胞移位产生新的毛发生长。β-连环蛋白的激活足以诱导毛发生长，而不依赖于毛发再生通常所需的间充质真皮乳头-利基信号。值得注意的是，野生型细胞被β-catenin突变细胞吸引到新的毛发生长中，非细胞细胞通过Wnt配体自主激活野生型细胞内的Wnt信号。这项研究证明了Wnt/β-catenin信号自主地控制干细胞依赖的非细胞组织生长的机制，并促进了我们对驱动协调再生的机制的理解。
Wnt/β-catenin signaling is critical for tissue regeneration. However, it is unclear how β-catenin controls stem cell behaviors to coordinate organized growth. Using live imaging, we show that activation of β-catenin specifically within mouse hair follicle stem cells generates new hair growth through oriented cell divisions and cellular displacement. β-catenin activation is sufficient to induce hair growth independently of mesenchymal dermal papilla-niche signals normally required for hair regeneration. Remarkably, wild-type cells are co-opted into new hair growths by β-catenin mutant cells, which non-cell autonomously activate Wnt signaling within the wild-type cells via Wnt ligands. This study demonstrates a mechanism by which Wnt/β-catenin signaling controls stem cell-dependent tissue growth non–cell autonomously and advances our understanding of the mechanisms that drive coordinated regeneration.
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影响因子：
64.8
作者：
Rompolas, Panteleimon;Deschene, Elizabeth R.;Zito, Giovanni;Gonzalez, David G.;Saotome, Ichiko;Haberman, Ann M.;Greco, Valentina
通讯作者：
Greco, Valentina
影响因子：
21.3
作者：
Devenport, Danelle;Fuchs, Elaine
通讯作者：
Fuchs, Elaine
影响因子：
25
作者：
Madisen L;Zwingman TA;Sunkin SM;Oh SW;Zariwala HA;Gu H;Ng LL;Palmiter RD;Hawrylycz MJ;Jones AR;Lein ES;Zeng H
通讯作者：
Zeng H
影响因子：
4.6
作者：
Narhi, Katja;Jarvinen, Elina;Thesleff, Irma
通讯作者：
Thesleff, Irma
影响因子：
6.5
作者：
Myung, Peggy S.;Takeo, Makoto;Ito, Mayumi;Atit, Radhika P.
通讯作者：
Atit, Radhika P.