Effect of salidroside on lung injury by upregulating peroxisome proliferator-activated receptor γ expression in septic rats.
Effect of salidroside on lung injury by upregulating peroxisome proliferator-activated receptor γ expression in septic rats.
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DOI：
10.3892/etm.2014.1629
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发表时间：
2014-06
影响因子：
2.7
通讯作者：
Wang YH
中科院分区：
文献类型：
--
作者：
Liu MW;Su MX;Qin LF;Liu X;Tian ML;Zhang W;Wang YH
脓毒症相关急性肺损伤（ALI）的成功药物治疗仍然是一个主要的临床问题。因此，本研究的目的是研究红景天苷对改善盲肠结扎穿孔（CLP）诱导的肺部炎症的有益作用。采用CLP手术诱导大鼠急性肺损伤模型，腹腔注射红景天苷800 mg/kg（i. v.）在CLP攻击后24小时施用。随后，分析了与炎症和损伤相关的血液和肺组织中的生化变化以及肺中的形态学和组织学变化。CLP可显著升高血浆肿瘤坏死因子-α和白细胞介素-6、-1β和-10的血清水平。此外，CLP增加肺水肿，增厚肺泡隔，并引起肺细胞炎症。这些变化通过给予800 mg/kg红景天苷（i. v.）CLP激发后24 h。该治疗后给药还显著减弱了脂多糖诱导的核因子-κβ活化，并增加了肺组织中过氧化物酶体增殖物激活受体γ的释放。因此，红景天苷在CLP诱导的ALI后给药可显著预防和逆转肺组织损伤。红景天苷给药的积极治疗后效果表明，红景天苷可能是治疗CLP诱导的内毒素血症和感染性休克中肺部炎症的潜在候选药物。
Successful drug treatment for sepsis-related acute lung injury (ALI) remains a major clinical problem. Thus, the aim of the present study was to investigate the beneficial effects of salidroside on ameliorating cecal ligation and puncture (CLP)-induced lung inflammation. Rats underwent CLP surgery to induce ALI and 800 mg/kg salidroside (i.v.) was administered 24 h after the CLP challenge. Subsequently, biochemical changes in the blood and lung tissues, as well as morphological and histological alterations in the lungs, that were associated with inflammation and injury were analysed. CLP was shown to significantly increase the serum levels of plasma tumour necrosis factor-α and interleukin-6, -1β and-10. In addition, CLP increased pulmonary oedema, thickened the alveolar septa and caused inflammation in the lung cells. These changes were ameliorated by the administration of 800 mg/kg salidroside (i.v.) 24 h after the CLP challenge. This post-treatment drug administration also significantly attenuated the lipopolysaccharide-induced activation of nuclear factor-κβ and increased the release of peroxisome proliferator-activated receptor γ in the lung tissue. Therefore, salidroside administered following the induction of ALI by CLP significantly prevented and reversed lung tissue injuries. The positive post-treatment effects of salidroside administration indicated that salidroside may be a potential candidate for the management of lung inflammation in CLP-induced endotoxemia and septic shock.
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影响因子：
15.1
作者：
Kuempers, Philipp;Gueler, Faikah;Shushakova, Nelli
通讯作者：
Shushakova, Nelli
DOI：
10.1073/pnas.97.9.4844
发表时间：
2000-04-25
影响因子：
11.1
作者：
Straus, DS;Pascual, G;Glass, CK
通讯作者：
Glass, CK
影响因子：
4.4
作者：
Gupta, Naveen;Su, Xiao;Matthay, Michael A.
通讯作者：
Matthay, Michael A.
影响因子：
2.5
作者：
Hunter, Randy L.;Choi, Dong-Young;Bing, Guoying
通讯作者：
Bing, Guoying
影响因子：
3.3
作者：
Berthiaume, Y;Folkesson, HG;Matthay, MA
通讯作者：
Matthay, MA