Dorsal striatum mediation of cocaine-seeking after withdrawal from short or long daily access cocaine self-administration in rats.
Dorsal striatum mediation of cocaine-seeking after withdrawal from short or long daily access cocaine self-administration in rats.
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DOI：
10.1016/j.bbr.2010.12.014
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发表时间：
2011-04-15
影响因子：
2.7
通讯作者：
See, Ronald E.
中科院分区：
文献类型：
--
作者：
Pacchioni, Alejandra M.;Gabriele, Amanda;See, Ronald E.
越来越多的证据表明，长期使用可卡因可能会导致从腹侧到纹状体背侧区域的渐进性神经适应。我们以前发现，可逆失活的背外侧尾状核/壳核（dlCPu）显着衰减可卡因寻求大鼠慢性可卡因自我管理和退出。由于可卡因摄入的累积量和戒断紧急模式的时间过程先前已被证明会改变随后的可卡因寻求，因此本研究调查了在可卡因自我给药和禁欲时间点的不同访问期后dlCPu在可卡因寻求中的作用。将大鼠插入导管并在dlCPu中植入输注插管，训练可卡因自我给药（0.2 mg/50 ul/输注），然后允许每天自我给药可卡因1或6小时。在最后一次治疗后，动物在戒断的第1、14和60天，在双侧向dlCPu输注巴曲酶-蝇蕈醇或载体后立即在自我给药的背景下进行三次单独的可卡因寻找测试。虽然灭活的dlCPu的baclant-muscimol导致减少可卡因寻求在两组中，抑制反应的程度与访问历史和戒断时间点。虽然这些数据支持背侧纹状体区域在可卡因寻求中的作用，但更大的先前可卡因摄入量并不导致戒断后可卡因寻求对完整dlCPu功能的更大依赖。
Accumulating evidence has suggested that prolonged use of cocaine may lead to progressive neuroadaptations proceeding from ventral to more dorsal areas of the corpus striatum. We have previously found that reversible inactivation of the dorsolateral caudate/putamen (dlCPu) significantly attenuated cocaine-seeking in rats following chronic cocaine self-administration and withdrawal. Since the cumulative amount of cocaine intake and the time course of withdrawal emergent patterns have been previously shown to alter subsequent cocaine-seeking, the current study investigated the role of the dlCPu in cocaine-seeking after differing access periods of cocaine self-administration and abstinence time points. Rats were catheterized and implanted with infusion cannulae in the dlCPu, trained on cocaine self-administration (0.2 mg/50 ul/infusion), and then allowed to self-administer cocaine for 1 or 6 h daily sessions. After the final session, animals underwent three separate tests of cocaine-seeking in the self-administration context at days 1, 14, and 60 of abstinence immediately following bilateral infusion of baclofen-muscimol or vehicle into the dlCPu. While inactivation of the dlCPu by baclofen-muscimol resulted in reduced cocaine-seeking in both groups, the degree of inhibited responding varied with access history and withdrawal time point. While these data support a role for dorsal striatal regions in cocaine-seeking, greater previous cocaine intake did not lead to a greater dependence on intact dlCPu function for cocaine-seeking after abstinence.
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10.1124/jpet.107.122861
发表时间：
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影响因子：
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作者：
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