Role of dopamine D(1)-family receptors in dorsolateral striatum in context-induced reinstatement of heroin seeking in rats.
Role of dopamine D(1)-family receptors in dorsolateral striatum in context-induced reinstatement of heroin seeking in rats.
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DOI：
10.1007/s00213-009-1580-x
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发表时间：
2009-09
影响因子：
3.4
通讯作者：
Shaham, Yavin
中科院分区：
文献类型：
--
作者：
Bossert, Jennifer M.;Wihbey, Kristina A.;Pickens, Charles L.;Nair, Sunila G.;Shaham, Yavin
关键词：
对于人类来说，暴露于先前与海洛因摄入相关的环境可能会导致吸毒复发。在老鼠中，在不同环境下的药物强化反应消失后，暴露于海洛因相关环境会恢复海洛因寻求。这种效应可通过阻断伏隔核外侧或内侧的 D1 家族受体而减弱，但伏隔核不会减弱。在这项研究中，我们通过评估背外侧或背内侧注射 D1 家族受体拮抗剂 SCH 23390 对这种恢复的影响，进一步描述了纹状体 D1 家族受体在环境诱导恢复中的作用。训练大鼠自行注射海洛因（每次输注 0.05-0.10 毫克/千克）12 天；药物输注与离散的音调灯光提示配对。随后，在非毒品环境中存在离散提示的情况下，海洛因强化的杠杆按压被熄灭。在灭绝条件下的恢复测试中，在暴露于海洛因自我给药环境或非药物（灭绝）环境之前，将 D1 家族受体拮抗剂 SCH 23390（每侧 0.3-1.0 µg）注射到背外侧或背内侧纹状体中。然后，我们使用断开程序来检查背外侧纹状体和外侧伏隔核壳中的 D1 家族受体是否共同或独立支持环境诱导的恢复。背外侧而非背内侧 SCH 23390 注射减弱了环境诱导的海洛因寻求恢复。 SCH 23390注射到一个半球的背外侧纹状体和另一半球的外侧伏隔核壳中是无效的。结果表明，背外侧纹状体 D1 家族多巴胺受体对于环境诱导的海洛因寻求恢复至关重要。结果还表明，背外侧纹状体和侧伏核壳中 D1 受体介导的多巴胺传递独立支持这种恢复。
In humans, exposure to environmental contexts previously associated with heroin intake can provoke relapse to drug use. In rats, exposure to heroin-associated contexts after extinction of drug-reinforced responding in different contexts reinstates heroin seeking. This effect is attenuated by blockade of D1-family receptors in lateral or medial accumbens shell, but not accumbens core. In this study, we further characterized the role of striatal D1-family receptors in context-induced reinstatement by assessing the effect of dorsolateral or dorsomedial injections of the D1-family receptor antagonist SCH 23390 on this reinstatement. Rats were trained to self-administer heroin (0.05–0.10 mg/kg per infusion) for 12 days; drug infusions were paired with a discrete tone–light cue. Subsequently, heroin-reinforced lever pressing was extinguished in the presence of the discrete cue in a nondrug context. During reinstatement tests under extinction conditions, the D1-family receptor antagonist SCH 23390 (0.3–1.0µg per side) was injected into the dorsolateral or dorsomedial striatum prior to exposure to heroin self-administration context or the nondrug (extinction) context. We then used a disconnection procedure to examine whether D1-family receptors in the dorsolateral striatum and lateral accumbens shell jointly or independently support context-induced reinstatement. Dorsolateral but not dorsomedial SCH 23390 injections attenuated context-induced reinstatement of heroin seeking. SCH 23390 injections into the dorsolateral striatum of one hemisphere and lateral accumbens shell of the other hemisphere were ineffective. Results indicate that dorsolateral striatum D1-family dopamine receptors are critical for context-induced reinstatement of heroin seeking. Results also suggest that D1-receptor-mediated dopamine transmission in the dorsolateral striatum and lateral accumbens shell independently support this reinstatement.
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影响因子：
3.4
作者：
Millan, MJ;Newman-Tancredi, A;Cussac, D
通讯作者：
Cussac, D
DOI：
10.1111/j.1749-6632.1992.tb25984.x
发表时间：
1992-06-28
影响因子：
5.2
作者：
OBRIEN, CP;CHILDRESS, AR;EHRMAN, R
通讯作者：
EHRMAN, R
影响因子：
2.5
作者：
GROENEWEGEN, HJ;RUSSCHEN, FT
通讯作者：
RUSSCHEN, FT
影响因子：
3.3
作者：
Hamlin, A. S.;Clemens, K. J.;Mcnally, G. P.
通讯作者：
Mcnally, G. P.
影响因子：
7.3
作者：
BRIGGS, CA;POLLOCK, NJ;KEBABIAN, JW
通讯作者：
KEBABIAN, JW