Hypophysectomized rats depend on residual prolactin for survival.
Hypophysectomized rats depend on residual prolactin for survival.
复制标题
垂体切除的大鼠依靠残留的催乳素生存。
DOI：
10.1210/endo-128-6-2776
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发表时间：
1991
期刊：
影响因子：
4.8
通讯作者：
I. Bérczi
中科院分区：
文献类型：
--
作者：
É. Nagy;I. Bérczi
通过Nb 2淋巴瘤增殖试验，与对照组相比，垂体切除（Hypox）雌性Fischer 344大鼠血清中的催乳活性为10-20%。如果这些动物每天用兔抗大鼠PRL血清治疗，它们的血清催乳活性进一步降低;严重的贫血和免疫无能的发展;和死亡发生在8周内。相比之下，未经处理的Hypox动物逐渐增加其血清催乳活性，从垂体切除后第7周开始，到第9周上升至对照水平的50%。缺氧动物表现出正常色素性正常红细胞性贫血，免疫能力显著降低，体重、胸腺、脾脏、肾上腺和卵巢重量降低，胸腺、脾脏和骨髓中DNA和RNA合成减少。然而，Hypox动物的状况在9周的实验期间没有进一步恶化。在移植同系垂体（SPG）后，在Hypox大鼠中观察到的所有血液学缺陷和器官重量下降均正常化。SPG的这些作用可被抗大鼠PRL血清所抑制。用绵羊PRL处理Hypox动物具有与SPG相似的恢复作用，其不受额外抗大鼠PRL血清处理的抑制。大鼠和绵羊PRL和GH和人胎盘催乳素都刺激大鼠骨髓细胞在体外掺入3 H-胸苷。这些结果表明，PRL具有多重营养作用，能够长时间维持重要的身体功能。
Hypophysectomized (Hypox) female Fischer 344 rats had 10-20% lactogenic activity in their serum when compared to controls by the Nb2 lymphoma proliferation assay. If such animals were treated daily with a rabbit antirat PRL serum, their serum lactogenic activity diminished further; severe anemia and immunological anergy developed; and death occurred within 8 weeks. In contrast, untreated Hypox animals increased gradually their serum lactogenic activity, starting on the 7th week after pituitary removal, which rose up to 50% of control levels by week 9. Hypox animals showed normochromic normocytic anemia, a grossly reduced immunocompetence, decreased body, thymus, spleen, adrenal, and ovary weights, and decreased DNA and RNA synthesis in the thymus, spleen, and bone marrow. However, the condition of Hypox animals did not deteriorate further over the 9-week experimental period. All the hematological deficiencies and decrease in organ weights observed in Hypox rats were normalized after grafting with syngeneic pituitaries (SPG). These effects of SPG could be inhibited by additional treatment with antirat PRL serum. Treatment of Hypox animals with ovine PRL had a restoring effect similar to SPG, which was not inhibited by additional antirat PRL serum treatment. Rat and ovine PRL and GH and human placental lactogen all stimulated the incorporation of 3H-thymidine by rat bone marrow cells in vitro. These results indicate that PRL has a multiple trophic effect and is capable of maintaining vital bodily functions for long periods of time.
影响因子：
5.8
作者：
K. W. Kelley
通讯作者：
K. W. Kelley
刀豆球蛋白 A 刺激的小鼠脾细胞产生具有催乳素样生物活性和免疫反应性的因子。
DOI：
10.1016/0006-291x(87)91020-5
发表时间：
1987
影响因子：
3.1
作者：
Montgomery,DW;Zukoski,CF;Shah,GN;Buckley,AR;Pacholczyk,T;Russell,DH
通讯作者：
Russell,DH