Electrophysiological properties of neurones in the internal and external submucous plexuses of newborn pig small intestine.
Electrophysiological properties of neurones in the internal and external submucous plexuses of newborn pig small intestine.
复制标题
新生猪小肠内外粘膜下丛神经元的电生理特性。
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
E. Skadhauge
中科院分区：
文献类型：
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作者：
L. Thomsen;G. Pearson;E. Larsen;E. Skadhauge
1. 使用细胞内微电极识别猪小肠内部和外部粘膜下神经丛中神经元的三个主要电生理类别。 2. 两类神经元在其动作电位后具有持久的后超极化，通过是否存在快速兴奋性突触输入（EPSP）来区分，被称为 AH 神经元。 S 神经元接受快速 EPSP，但没有表现出后超极化。 3.三组神经元的平均静息膜电位在两个神经丛中表现出相似的趋势，AH神经元的两组的值明显高于S神经元的值。没有检测到输入电阻随细胞类型的显着变化。内部粘膜下丛的神经元输入阻力显着大于外部粘膜下丛。 4. 内部粘膜下丛中超过 80% 的 AH 神经元显示出快速 EPSP，但外部粘膜下丛中类似比例的 AH 神经元未显示快速 EPSP。 S 神经元占内部粘膜下神经丛细胞群的 60%，但仅占外部粘膜下神经丛细胞群的不到 30%。 5. 这项针对猪粘膜下神经元的研究揭示了与之前在豚鼠小肠中的研究的相似之处和不同之处。最具对比的特征是猪中 AH 神经元的相对丰富和亚分类，以及慢突触电位的明显缺乏。内部和外部粘膜下神经丛的神经元分布的差异可能反映了两个肠神经网络之间的功能差异。
1. Intracellular microelectrodes were used to identify three major electrophysiological categories of neurone in both the internal and external submucous plexuses of the porcine small intestine. 2. Two classes of neurone with a long‐lasting after‐hyperpolarization following their action potential were differentiated by the presence or absence of fast excitatory synaptic inputs (EPSPs) and were termed AH neurones. S neurones received fast EPSPs but did not display after‐hyperpolarizations. 3. The mean resting membrane potentials of the three groups of neurones showed a similar trend in both plexuses, with significantly higher values for the two populations of AH neurone than for S neurones. No significant variation of input resistance with cell type was detected. Neuronal input resistance was significantly greater in the internal submucous plexus than in the external submucous plexus. 4. Over 80% of AH neurones in the internal submucous plexus displayed fast EPSPs but a similar percentage of AH neurones in the external submucous plexus did not show fast EPSPs. S neurones constituted 60% of cells studied in the internal submucous plexus but less than 30% of the cell population in the external submucous plexus. 5. This study of porcine submucous neurones has revealed both similarities and differences to previous work in the guinea‐pig small intestine. The most contrasting features are the relative abundance and subclassification of AH neurones in the pig in addition to the apparent paucity of slow synaptic potentials. The differences in the neuronal profiles of the internal and external submucous plexuses may reflect a differentiation of function between the two enteric nerve networks.
P物质通过作用于肠神经元在猪空肠粘膜中产生钠和碳酸氢盐分泌。
DOI：
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发表时间：
1992
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
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作者：
Brown,DR;Parsons,AM;O'Grady,SM
通讯作者：
O'Grady,SM
DOI：
10.1152/ajpregu.1989.256.2.r481
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
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作者：
Carey,HV;Cooke,HJ
通讯作者：
Cooke,HJ