Shared genetic influence on frailty and chronic widespread pain: a study from TwinsUK.
Shared genetic influence on frailty and chronic widespread pain: a study from TwinsUK.
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DOI：
10.1093/ageing/afx122
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发表时间：
2018-01-01
期刊：
影响因子：
6.7
通讯作者：
Williams FMK
中科院分区：
文献类型：
--
作者：
Livshits G;Ni Lochlainn M;Malkin I;Bowyer R;Verdi S;Steves CJ;Williams FMK
脆弱是指在环境和遗传驱动因素的作用下，在多个生理系统中，对不利健康结果的脆弱性增加。两种最常用的测量方法是罗克伍德的虚弱指数（FI）和弗里德的虚弱表型（FP）。本研究包括来自TwinsUK成人双胞胎登记处的3626名个体。我们使用经典的双胞胎模型来确定FI和FP是否具有相同的潜在病因学因素。我们还调查了虚弱和慢性广泛性肌肉骨骼疼痛（CWP）之间的关系，这是另一种具有显著临床影响的整体年龄相关疾病。FP和FI具有共同的遗传和环境病因。CWP与两种脆弱性指标相关，健康缺陷似乎介导了表型脆弱性和疼痛之间的关系。潜在的遗传因素支持CWP与脆弱。虽然脆弱性增加的双胞胎报告疼痛，双胞胎回归分析表明，CWP和脆弱性之间的关系减少后，占共享的遗传和环境因素。这两种脆弱性的衡量方法都有相同的根源，因此这项工作有助于统一脆弱性研究。我们证实了CWP和虚弱之间的强关联，并显示了这两种现象的大而显着的共同遗传病因。我们的研究结果反对疼痛是一个重要的致病因素，在发展的脆弱性，有利于共同的因果关系。这项研究强调了需要管理体弱个体的CWP，并对患有CWP的个体进行综合老年评估。最后，寻找支持CWP和虚弱的遗传因素可以通过整合疼痛和虚弱的措施来帮助。
frailty is an increased vulnerability to adverse health outcomes, across multiple physiological systems, with both environmental and genetic drivers. The two most commonly used measures are Rockwood’s frailty index (FI) and Fried’s frailty phenotype (FP). the present study included 3626 individuals from the TwinsUK Adult Twin Registry. We used the classical twin model to determine whether FI and FP share the same latent aetiological factors. We also investigated the relationship between frailty and chronic widespread musculoskeletal pain (CWP), another holistic age-related condition with significant clinical impact. FP and FI shared underlying genetic and environmental aetiology. CWP was associated with both frailty measures, and health deficits appeared to mediate the relationship between phenotypic frailty and pain. Latent genetic factors underpinning CWP were shared with frailty. While frailty was increased in the twins reporting pain, co-twin regression analysis indicated that the relationship between CWP and frailty is reduced after accounting for shared genetic and environmental factors. both measures of frailty tap the same root causes, thus this work helps unify frailty research. We confirmed a strong association between CWP and frailty, and showed a large and significant shared genetic aetiology of both phenomena. Our findings argue against pain being a significant causative factor in the development of frailty, favouring common causation. This study highlights the need to manage CWP in frail individuals and undertake a Comprehensive Geriatric Assessment in individuals presenting with CWP. Finally, the search for genetic factors underpinning CWP and frailty could be aided by integrating measures of pain and frailty.
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DOI：
10.1093/gerona/glw226
发表时间：
2017-03-01
影响因子：
5.1
作者：
Wade, Katie F.;Marshall, Alan;Lee, David M.
通讯作者：
Lee, David M.
影响因子：
--
作者：
Dato, Serena;Montesanto, Alberto;Passarino, Giuseppe
通讯作者：
Passarino, Giuseppe
影响因子：
7.4
作者：
Livshits G;Macgregor AJ;Gieger C;Malkin I;Moayyeri A;Grallert H;Emeny RT;Spector T;Kastenmüller G;Williams FMK
通讯作者：
Williams FMK
影响因子：
0.9
作者：
Young, Aideen C. M.;Glaser, Karen;Steves, Claire J.
通讯作者：
Steves, Claire J.
影响因子：
14.6
作者：
Rockwood, K;Song, XW;Mitnitski, A
通讯作者：
Mitnitski, A