Recent Progress on Exosomes in RNA Virus Infection.
Recent Progress on Exosomes in RNA Virus Infection.
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DOI：
10.3390/v13020256
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发表时间：
2021-02-08
期刊：
影响因子：
--
通讯作者：
Ren L
中科院分区：
文献类型：
--
作者：
Zhang L;Ju Y;Chen S;Ren L
最近的研究表明，大多数组织和细胞类型都可以分泌和释放膜封闭的小囊泡，称为外泌体，其内容反映了其来源细胞的生理/病理状态。这些外泌体参与生物活性蛋白质、脂质和核酸的通讯和细胞间转移。 RNA病毒的研究表明，外泌体从受感染的细胞中释放调节因子，并将其他功能性宿主遗传元件传递到邻近细胞，这些功能参与感染过程并调节细胞反应。这篇综述概述了外泌体分泌的生物发生、组成和一些最显着的功能，并确定了需要进一步研究的生理/病理领域。虽然初步迹象表明外泌体介导的途径在体内发挥作用，但参与相关作用的外泌体机制仍需要澄清。目前的综述重点关注外泌体在 RNA 病毒感染中的作用，重点是外泌体对发病机制的潜在贡献。
Recent research indicates that most tissue and cell types can secrete and release membrane-enclosed small vesicles, known as exosomes, whose content reflects the physiological/pathological state of the cells from which they originate. These exosomes participate in the communication and cell-to-cell transfer of biologically active proteins, lipids, and nucleic acids. Studies of RNA viruses have demonstrated that exosomes release regulatory factors from infected cells and deliver other functional host genetic elements to neighboring cells, and these functions are involved in the infection process and modulate the cellular responses. This review provides an overview of the biogenesis, composition, and some of the most striking functions of exosome secretion and identifies physiological/pathological areas in need of further research. While initial indications suggest that exosome-mediated pathways operate in vivo, the exosome mechanisms involved in the related effects still need to be clarified. The current review focuses on the role of exosomes in RNA virus infections, with an emphasis on the potential contributions of exosomes to pathogenesis.
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DOI：
10.3390/v7062770
发表时间：
2015-06-19
期刊：
Viruses
影响因子：
--
作者：
Chahar HS;Bao X;Casola A
通讯作者：
Casola A
影响因子：
64.8
作者：
Feng Z;Hensley L;McKnight KL;Hu F;Madden V;Ping L;Jeong SH;Walker C;Lanford RE;Lemon SM
通讯作者：
Lemon SM
影响因子：
6.7
作者：
Barr SD;Smiley JR;Bushman FD
通讯作者：
Bushman FD
影响因子：
10.6
作者：
Anderson MR;Pleet ML;Enose-Akahata Y;Erickson J;Monaco MC;Akpamagbo Y;Velluci A;Tanaka Y;Azodi S;Lepene B;Jones J;Kashanchi F;Jacobson S
通讯作者：
Jacobson S
影响因子：
13.5
作者：
Chen, Li;Charrier, Alyssa;Zhou, Yu;Chen, Ruju;Yu, Bo;Agarwal, Kitty;Tsukamoto, Hidekazu;Lee, L. James;Paulaitis, Michael E.;Brigstock, David R.
通讯作者：
Brigstock, David R.