Emotional distress and pain catastrophizing predict cue-elicited opioid craving among chronic pain patients on long-term opioid therapy.
Emotional distress and pain catastrophizing predict cue-elicited opioid craving among chronic pain patients on long-term opioid therapy.
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DOI：
10.1016/j.drugalcdep.2022.109361
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发表时间：
2022-04-01
影响因子：
4.2
通讯作者：
Garland, Eric L.
中科院分区：
文献类型：
--
作者：
Parisi, Anna;Landicho, Hannah Louise;Hudak, Justin;Leknes, Siri;Froeliger, Brett;Garland, Eric L.
使用非法药物的个体在暴露于与过去吸毒有关的线索时，表现出线索诱发的渴望和自主线索反应。然而，对长期阿片类药物治疗（LTOT）的慢性疼痛患者的这种现象知之甚少。一般的消极认知情绪反应（如痛苦）和疼痛特有的认知情绪反应（如疼痛灾难化）可能会驱动与疼痛严重程度无关的线索反应。在这里，我们研究了情绪困扰和疼痛灾难化作为慢性疼痛患者接受ltt样本中线索反应的预测因子。我们还测试了阿片类药物滥用状态下，痛苦、灾难化和线索反应之间的关联是否存在差异。接受LTOT的患者（N=243）被分类为表现出与阿片类药物滥用一致的异常行为（滥用+，N= 145）或按规定使用阿片类药物（滥用-，N= 97）。参与者完成了疼痛灾难和情绪困扰的评估，然后在一周后参加了阿片类药物线索反应任务。线索引发的阿片类药物渴望和自主线索反应分别用渴望等级和高频心率变异性（HRV）来测量。痛苦和灾难预测线索引发的渴望和HRV，而疼痛严重程度没有。滥用者的状态调节了情绪困扰与自我报告的渴望之间的关系，因此，在滥用+组中，较高水平的痛苦预示着渴望，而在滥用-组中则没有。没有发现灾难化的调节效应。研究结果表明，尽管阿片类药物用于镇痛，但负面认知情绪反应（无论是一般的还是特定的疼痛）对线索引发的阿片类药物渴望的加剧影响超出了疼痛严重程度的影响。
Individuals who use illicit substances exhibit cue-elicited craving and autonomic cue-reactivity when exposed to cues associated with past drug use. However, little is known about this phenomenon among chronic pain patients on long-term opioid therapy (LTOT). Negative cognitive-emotional reactivity in general (e.g., distress) and cognitive-emotional reactivity specific to pain (e.g., pain catastrophizing) might drive cue-reactivity independent of pain severity. Here we examined emotional distress and pain catastrophizing as predictors of cue-reactivity among a sample of chronic pain patients receiving LTOT. We also tested whether associations between distress, catastrophizing, and cue-reactivity differed as a function of opioid misuse status. Patients receiving LTOT (N=243) were classified as exhibiting aberrant behavior consistent with opioid misuse (MISUSE+, n=145) or as using opioids as prescribed (MISUSE−, n=97). Participants completed assessments of pain catastrophizing and emotional distress and then participated in an opioid cue-reactivity task one week later. Cue-elicited opioid craving and autonomic cue-reactivity were measured with craving ratings and high-frequency heart rate variability (HRV), respectively. Distress and catastrophizing predicted cue-elicited craving and HRV, whereas pain severity did not. Misuser status moderated the relationship between emotional distress and self-reported craving, such that higher levels of distress predicted craving among the MISUSE+ group, but not among the MISUSE− group. No moderating effects were found for catastrophizing. Findings suggest that although opioids are prescribed for analgesia, the exacerbating influence of negative cognitive-emotional reactivity, both in general and specific to pain, on cue-elicited opioid craving extends beyond the effects of pain severity alone.
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影响因子：
2.9
作者：
Dorado K;Schreiber KL;Koulouris A;Edwards RR;Napadow V;Lazaridou A
通讯作者：
Lazaridou A
DOI：
10.1097/ajp.0b013e3181f195ba
发表时间：
2010-11
期刊：
The Clinical journal of pain
影响因子：
--
作者：
Butler SF;Budman SH;Fanciullo GJ;Jamison RN
通讯作者：
Jamison RN
影响因子：
2.3
作者：
Baker AK;Garland EL
通讯作者：
Garland EL
DOI：
10.1016/j.jpain.2008.10.008
发表时间：
2009-02
期刊：
The journal of pain
影响因子：
--
作者：
Chou R;Fanciullo GJ;Fine PG;Adler JA;Ballantyne JC;Davies P;Donovan MI;Fishbain DA;Foley KM;Fudin J;Gilson AM;Kelter A;Mauskop A;O'Connor PG;Passik SD;Pasternak GW;Portenoy RK;Rich BA;Roberts RG;Todd KH;Miaskowski C;American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel
通讯作者：
American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel
影响因子：
13.8
作者：
Darnall BD;Roy A;Chen AL;Ziadni MS;Keane RT;You DS;Slater K;Poupore-King H;Mackey I;Kao MC;Cook KF;Lorig K;Zhang D;Hong J;Tian L;Mackey SC
通讯作者：
Mackey SC