Autonomic and affective mediators of the relationship between mindfulness and opioid craving among chronic pain patients.
Autonomic and affective mediators of the relationship between mindfulness and opioid craving among chronic pain patients.
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DOI：
10.1037/pha0000225
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发表时间：
2019-03
影响因子：
2.3
通讯作者：
Garland EL
中科院分区：
文献类型：
--
作者：
Baker AK;Garland EL
慢性疼痛患者处方阿片类药物滥用与自我调节缺陷、情感痛苦和阿片类线索反应有关。性格正念与药物提示暴露后增强的自我调节、较低的痛苦和适应性自主反应有关。我们假设，在阿片类药物治疗的慢性疼痛患者中，性格正念可能是一种保护因素。我们检查了暴露于阿片类线索和抑郁情绪时的心率变异性（HRV）作为气质正念和阿片类药物渴望之间关联的中介。数据来自长期接受阿片类药物治疗的慢性疼痛患者样本（N=115）。参与者自我报告阿片类药物渴望和抑郁，并在阿片类线索点探测任务中测量HRV。性情正念与HRV显著正相关，HRV与阿片渴望显著负相关。性格正念与抑郁呈显著负相关，抑郁与阿片渴望呈显著正相关。通径分析显示，性格正念通过HRV和抑郁对渴望有显著的间接影响。处置正念可以缓冲处方阿片类药物的慢性疼痛患者对阿片类药物的渴望；这种缓冲作用可能是改善自主神经和情感反应的功能。
Prescription opioid misuse among chronic pain patients is associated with self-regulatory deficits, affective distress and opioid cue reactivity. Dispositional mindfulness has been associated with enhanced self-regulation, lower distress, and adaptive autonomic responses following drug cue exposure. We hypothesized that dispositional mindfulness might serve as a protective factor among opioid-treated chronic pain patients. We examined heart rate variability (HRV) during exposure to opioid cues and depressed mood as mediators of the association between dispositional mindfulness and opioid craving. Data were obtained from a sample of chronic pain patients (N=115) receiving long-term opioid pharmacotherapy. Participants self-reported opioid craving and depression, and HRV was measured during an opioid-cue dot probe task. Dispositional mindfulness was significantly positively correlated with HRV, and HRV was significantly inversely associated with opioid craving. Dispositional mindfulness was significantly negatively correlated with depression, and depression was significantly positively correlated with opioid craving. Path analysis revealed significant indirect effects of dispositional mindfulness on craving through both HRV and depression. Dispositional mindfulness may buffer against opioid craving among chronic pain patients prescribed opioids; this buffering effect may be a function of improved autonomic and affective responses.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1016/j.jpain.2008.10.008
发表时间：
2009-02
期刊：
The journal of pain
影响因子：
--
作者：
Chou R;Fanciullo GJ;Fine PG;Adler JA;Ballantyne JC;Davies P;Donovan MI;Fishbain DA;Foley KM;Fudin J;Gilson AM;Kelter A;Mauskop A;O'Connor PG;Passik SD;Pasternak GW;Portenoy RK;Rich BA;Roberts RG;Todd KH;Miaskowski C;American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel
通讯作者：
American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel
影响因子：
4.4
作者：
Back, Sudie E.;Gros, Daniel F.;McCauley, Jenna L.;Flanagan, Julianne C.;Cox, Elizabeth;Barth, Kelly S.;Brady, Kathleen T.
通讯作者：
Brady, Kathleen T.
DOI：
10.1017/cbo9780511546396.008
发表时间：
2007-01-01
期刊：
HANDBOOK OF PSYCHOPHYSIOLOGY, 3RD EDITION
影响因子：
--
作者：
Berntson, Gary G.;Quigley, Karen S.;Lozano, Dave
通讯作者：
Lozano, Dave
影响因子：
2.7
作者：
Carlson, Linda E.;Thomas, Bejoy Cherian
通讯作者：
Thomas, Bejoy Cherian