Viral-associated exacerbations of asthma and COPD.

Viral-associated exacerbations of asthma and COPD.
复制标题

DOI:
10.1016/j.coph.2006.11.010
复制
发表时间:
2007-06
影响因子:
4
通讯作者:
Proud D
Proud D
中科院分区:
医学3区
文献类型:
--
作者:
Traves SL;Proud D

文献摘要

参考文献

被引文献

相似文献

哮喘和慢性阻塞性肺疾病的加重是医疗保健系统的主要负担,并显著增加了与这些疾病相关的死亡率和发病率。上呼吸道病毒感染与大多数此类疾病恶化相关。在过去的几年里,我们已经看到了病毒感染诱导促炎趋化因子产生的机制的进展,并在我们的理解宿主的抗病毒和抗炎防御途径,可能会调节感染的反应。更全面地了解这些过程的分子基础可以阐明新的治疗方法,以减少这些恶化对生活质量和医疗费用的破坏性影响。
Exacerbations of asthma and chronic obstructive pulmonary disease are major burdens on the healthcare system, and contribute significantly to the mortality and morbidity associated with these diseases. Upper respiratory viral infections are associated with the majority of such disease exacerbations. The past few years have seen advances in the mechanisms by which viral infections induce pro-inflammatory chemokine production, and in our understanding of host antiviral and anti-inflammatory defence pathways that might regulate responses to infection. A more comprehensive understanding of the molecular basis of these processes could elucidate new therapeutic approaches to reduce the devastating impact that these exacerbations have on quality of life and healthcare costs.
DOI: 10.1164/rccm.200407-894oc
发表时间: 2005-02-15
影响因子: 24.7
作者:
Bisgaard, H;Zielen, S;Polos, P
通讯作者: Polos, P
DOI: 10.1038/35099560
发表时间: 2001-10-18
期刊: NATURE
影响因子: 64.8
作者:
Alexopoulou, L;Holt, AC;Flavell, RA
通讯作者: Flavell, RA
DOI: 10.1111/j.1365-2222.2005.02334.x
发表时间: 2005-10-01
影响因子: 6.1
作者:
de Kluijver, J;Schrumpf, JA;Sterk, PJ
通讯作者: Sterk, PJ
DOI: 10.1165/rcmb.2004-0417oc
发表时间: 2006-02-01
影响因子: 6.4
作者:
Chen, Y;Hamati, E;Wu, R
通讯作者: Wu, R
DOI: 10.1016/j.virol.2004.01.033
发表时间: 2004-05-01
期刊: VIROLOGY
影响因子: 3.7
作者:
Edelmann, KH;Richardson-Burns, S;Oldstone, MBA
通讯作者: Oldstone, MBA