Local and distant cortical responses to single pulse intracranial stimulation in the human brain are differentially modulated by specific stimulation parameters.
Local and distant cortical responses to single pulse intracranial stimulation in the human brain are differentially modulated by specific stimulation parameters.
复制标题
DOI：
10.1016/j.brs.2022.02.017
复制
发表时间：
2022-03
影响因子：
7.7
通讯作者：
Cash SS
中科院分区：
文献类型：
--
作者：
Paulk AC;Zelmann R;Crocker B;Widge AS;Dougherty DD;Eskandar EN;Weisholtz DS;Richardson RM;Cosgrove GR;Williams ZM;Cash SS
通过直接电刺激(DES)进行的电神经调节是一种越来越常见的治疗各种神经精神疾病的方法。不幸的是，治疗效果是不一致的，可能是因为我们对大量刺激参数空间和脑组织反应之间的关系了解有限。为了更好地了解不同参数如何引起不同的神经反应，我们系统地研究了单个脉冲诱发的皮质诱发电位(CCEP)作为刺激幅度、持续时间、大脑区域以及是否刺激灰质或白质的函数。我们测量了脑内记录的刺激反应的电压峰值幅度和曲线下面积(AUC)，作为距离刺激部位的距离、脉冲宽度、注入电流、相对于灰质和白质的位置以及被刺激的大脑区域(N=52，n=719个刺激部位)的函数。增加刺激脉冲宽度可增加刺激部位附近的反应。增加刺激幅度(电流)可非线性地增加诱发幅度和AUC。局部(15 Mm)，在灰质和白质交界处刺激引起更大的反应。相比之下，对于较远的部位(>；15 mm)，白质刺激始终比刺激灰质内或灰质附近产生更大的反应。对于扣带回、外侧额叶和外侧颞叶皮质刺激，刺激位置-反应曲线遵循不同的趋势。这些结果表明，更强的局部反应可能需要刺激灰白边界，而刺激白质可能需要网络激活。因此，为特定的解剖-功能结果量身定做的刺激参数可能是推进神经调节治疗的关键。
Electrical neuromodulation via direct electrical stimulation (DES) is an increasingly common therapy for a wide variety of neuropsychiatric diseases. Unfortunately, therapeutic efficacy is inconsistent, likely due to our limited understanding of the relationship between the massive stimulation parameter space and brain tissue responses. To better understand how different parameters induce varied neural responses, we systematically examined single pulse-induced cortico-cortico evoked potentials (CCEP) as a function of stimulation amplitude, duration, brain region, and whether grey or white matter was stimulated. We measured voltage peak amplitudes and area under the curve (AUC) of intracranially recorded stimulation responses as a function of distance from the stimulation site, pulse width, current injected, location relative to grey and white matter, and brain region stimulated (N=52, n=719 stimulation sites). Increasing stimulation pulse width increased responses near the stimulation location. Increasing stimulation amplitude (current) increased both evoked amplitudes and AUC nonlinearly. Locally (<15 mm), stimulation at the boundary between grey and white matter induced larger responses. In contrast, for distant sites (>15 mm), white matter stimulation consistently produced larger responses than stimulation in or near grey matter. The stimulation location-response curves followed different trends for cingulate, lateral frontal, and lateral temporal cortical stimulation. These results demonstrate that a stronger local response may require stimulation in the grey-white boundary while stimulation in the white matter could be needed for network activation. Thus, stimulation parameters tailored for a specific anatomical-functional outcome may be key to advancing neuromodulatory therapy.
登录
查看更多内容
影响因子：
5.7
作者：
Crocker, Britni;Ostrowski, Lauren;Paulk, Angelique C.
通讯作者：
Paulk, Angelique C.
影响因子：
3
作者：
Bastos AM;Schoffelen JM
通讯作者：
Schoffelen JM
影响因子：
--
作者：
Bronstein JM;Tagliati M;Alterman RL;Lozano AM;Volkmann J;Stefani A;Horak FB;Okun MS;Foote KD;Krack P;Pahwa R;Henderson JM;Hariz MI;Bakay RA;Rezai A;Marks WJ Jr;Moro E;Vitek JL;Weaver FM;Gross RE;DeLong MR
通讯作者：
DeLong MR
影响因子：
8.6
作者：
Benabid, AL;Benazzous, A;Pollak, P
通讯作者：
Pollak, P
影响因子：
4.6
作者：
Alizadeh, Mahdi;Kozlowski, Lauren;Sharan, Ashwini
通讯作者：
Sharan, Ashwini