Interneurons of fan-shaped body promote arousal in Drosophila.
Interneurons of fan-shaped body promote arousal in Drosophila.
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DOI：
10.1371/journal.pone.0277918
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
睡眠是维持生理功能所必需的，并且在物种中广泛保守。为了了解睡眠调节机制，我们研究了各种动物的睡眠调节基因和神经回路。在黑腹果蝇的睡眠调节神经回路中，背扇形体（dFB）是一个主要的睡眠促进区。然而，其他调节睡眠的神经回路还没有被很好地识别出来。我们最近发现，促进觉醒的T1多巴胺神经元、原脑桥（PB）神经元的中间神经元和支配FB腹侧的PB神经元形成了一个睡眠调节回路，我们将其命名为“PB-FB通路”。在对其他睡眠调节回路的探索中，我们发现FB中间神经元（也被称为脑桥神经元）的激活促进了觉醒。然后我们发现FB中间神经元可能与PB-FB通路和dFB神经元有联系。Ca2+成像显示FB中间神经元接受来自PB-FB通路的兴奋性信号。我们还证明了FB中间神经元在调节dFB神经元中的可能作用。这些结果提示FB中间神经元在睡眠调节中的作用。
Sleep is required to maintain physiological functions and is widely conserved across species. To understand the sleep-regulatory mechanisms, sleep-regulating genes and neuronal circuits are studied in various animal species. In the sleep-regulatory neuronal circuits in Drosophila melanogaster, the dorsal fan-shaped body (dFB) is a major sleep-promoting region. However, other sleep-regulating neuronal circuits were not well identified. We recently found that arousal-promoting T1 dopamine neurons, interneurons of protocerebral bridge (PB) neurons, and PB neurons innervating the ventral part of the FB form a sleep-regulatory circuit, which we named “the PB-FB pathway”. In the exploration of other sleep-regulatory circuits, we found that activation of FB interneurons, also known as pontine neurons, promoted arousal. We then found that FB interneurons had possible connections with the PB-FB pathway and dFB neurons. Ca2+ imaging revealed that FB interneurons received excitatory signals from the PB-FB pathway. We also demonstrated the possible role of FB interneurons to regulate dFB neurons. These results suggested the role of FB interneurons in sleep regulation.
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影响因子：
64.5
作者：
Asahina K;Watanabe K;Duistermars BJ;Hoopfer E;González CR;Eyjólfsdóttir EA;Perona P;Anderson DJ
通讯作者：
Anderson DJ
影响因子：
4.3
作者：
Tomita J;Ban G;Kato YS;Kume K
通讯作者：
Kume K
影响因子：
5.3
作者：
Kume, K;Kume, S;Jackson, FR
通讯作者：
Jackson, FR
影响因子：
16.2
作者：
Gordon, Michael D.;Scott, Kristin
通讯作者：
Scott, Kristin
影响因子：
64.8
作者：
Li W;Wang Z;Syed S;Lyu C;Lincoln S;O'Neil J;Nguyen AD;Feng I;Young MW
通讯作者：
Young MW