Expression of Four Autophagy-Related Genes Accurately Predicts the Prognosis of Gastrointestinal Cancer in Asian Patients.
Expression of Four Autophagy-Related Genes Accurately Predicts the Prognosis of Gastrointestinal Cancer in Asian Patients.
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四种自噬相关基因的表达准确预测亚洲患者胃肠癌的预后。
DOI：
10.1155/2021/7253633
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Tang H;Liang Y;Xu S;Xia R;Shen J;Zhang Y;Gong X;Min Y;Zhang D;Zhao T;Wang S;Zhang Y;Wang C
胃肠道（GI）癌症是世界上最致命的疾病之一。大量的研究已经证实了自噬与胃肠道肿瘤的发生发展之间的关系。然而，自噬相关基因是否可以预测亚洲血统个体的GI癌症预后尚未确定。本研究旨在探讨自噬相关基因在胃肠道肿瘤中的预后价值。从TCGA数据库（TCGA-LIHC、TCGA-STAD、TCGA-ESCA、TCGA-PAAD、TCGA-COAD、TCGA-CHOL和TCGA-READ）下载296例亚洲血统胃肠癌患者的自噬相关基因表达谱。采用单变量考克斯、LASSO和多变量考克斯回归分析评估自噬相关基因的预后价值。计算自噬相关基因标签的风险评分，以评估其对GI癌症的预测预后价值。在亚洲胃肠癌患者中，鉴定了47个差异表达的自噬相关基因。在47个基因中，4个与GI癌的预后相关（SQSTM 1、BIRC 5、NRG 3和CXCR 4）。基于上述4个基因在训练集中的表达的GI癌症预后模型显示，癌症患者被分层为高风险组和低风险组（P < 0.05）。GI癌症患者的总生存期（OS）模型的效用在整个集、训练集和测试集上是一致的（整个集：P = 4.568 × 10−4;训练集：P = 5.718 × 10−3;测试集：P = 3.516 × 10−2）。上述预后模型的ROC曲线预测GI癌5年预后的敏感性和特异性令人满意（全集：0.728;训练集：0.727;测试集：0.733）。临床样品的分析验证了4种基因（SQSTM 1、BIRC 5、NRG 3和CXCR 4）在肿瘤组织中相对于配对正常组织的过表达，与生物信息学发现一致。自噬相关基因SQSTM 1、BIRC 5、NRG 3和CXCR 4的表达可准确预测亚洲胃肠道肿瘤患者的预后。
Gastrointestinal (GI) cancers are among the most fatal diseases in the world. Numerous studies have demonstrated the relationship between autophagy and development of gastrointestinal cancers. However, whether autophagy-related genes can predict prognosis of GI cancers in individuals of Asian ancestry has not been defined. This study, evaluated the prognostic value of autophagy-related genes in gastrointestinal cancer. Expression profile of autophagy-related genes for 296 gastrointestinal cancer patients of Asian ancestry was downloaded from the TCGA database (TCGA-LIHC, TCGA-STAD, TCGA-ESCA, TCGA-PAAD, TCGA-COAD, TCGA-CHOL, and TCGA-READ). The prognostic value of the autophagy-related genes was evaluated using univariate Cox, LASSO, and multivariate Cox regression analyses. The risk score of the autophagy-related gene signature was calculated to assess its predictive prognostic value for GI cancers. Forty-seven differentially expressed autophagy-related genes, in Asian patients with gastrointestinal cancers, were identified. Of the 47 genes, 4 were associated with prognosis of GI cancer (SQSTM1, BIRC5, NRG3, and CXCR4). A prognostic model for GI cancer, based on the expression of the above 4 genes in the training set, showed that cancer patients were stratified into high-risk and low-risk groups (P < 0.05). The utility of the model for overall survival (OS) of GI cancer patients was consistent across the entire set, training set, and test set (entire set: P = 4.568 × 10−4; train set: P = 5.718 × 10−3; test set: P = 3.516 × 10−2). The sensitivity and specificity of the ROC curve of the above prognostic model in predicting the 5-year prognosis of GI cancer was satisfactory (entire set: 0.728; train set: 0.727; test set: 0.733). Analysis of clinical samples validated the overexpression of the 4 genes (SQSTM1, BIRC5, NRG3, and CXCR4) in tumor tissues relative to paired normal tissues, consistent with bioinformatic findings. Expression of the 4 autophagy-related genes (SQSTM1, BIRC5, NRG3, and CXCR4) can accurately predict the prognosis of gastrointestinal tumors in Asian patients.
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