Diffuse Gastric Cancer: A Summary of Analogous Contributing Factors for Its Molecular Pathogenicity.
Diffuse Gastric Cancer: A Summary of Analogous Contributing Factors for Its Molecular Pathogenicity.
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DOI：
10.3390/ijms19082424
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发表时间：
2018-08-16
影响因子：
5.6
通讯作者：
Yamaoka Y
中科院分区：
文献类型：
--
作者：
Ansari S;Gantuya B;Tuan VP;Yamaoka Y
胃癌是癌症相关死亡的第三大原因，并在全球范围内排名第五。发病率和死亡率因地理区域而异，胃癌在东亚国家排名第一。虽然遗传因素、胃环境和幽门螺杆菌感染与Correa级联反应后的胃肠道型胃癌的致病性和发展相关，但弥漫型胃癌的致病性仍然大多未知和不确定。然而，细胞粘附因子的遗传异常，如E-钙粘蛋白和细胞活动，导致受损的细胞完整性和生理学，已被记录为促成因素。近年来，H.幽门螺杆菌感染也与弥漫型胃癌的发生有关。因此，在这份报告中，我们讨论了宿主因素以及细菌因素，已被报道为相关因素，促进弥漫型胃癌的发展。
Gastric cancer is the third leading cause of cancer-related deaths and ranks as the fifth most common cancer worldwide. Incidence and mortality differ depending on the geographical region and gastric cancer ranks first in East Asian countries. Although genetic factors, gastric environment, and Helicobacter pylori infection have been associated with the pathogenicity and development of intestinal-type gastric cancer that follows the Correa’s cascade, the pathogenicity of diffuse-type gastric cancer remains mostly unknown and undefined. However, genetic abnormalities in the cell adherence factors, such as E-cadherin and cellular activities that cause impaired cell integrity and physiology, have been documented as contributing factors. In recent years, H. pylori infection has been also associated with the development of diffuse-type gastric cancer. Therefore, in this report, we discuss the host factors as well as the bacterial factors that have been reported as associated factors contributing to the development of diffuse-type gastric cancer.
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影响因子：
--
作者：
Bellini MF;Cadamuro AC;Succi M;Proença MA;Silva AE
通讯作者：
Silva AE
影响因子：
6.2
作者：
Das L;Kokate SB;Dixit P;Rath S;Rout N;Singh SP;Crowe SE;Bhattacharyya A
通讯作者：
Bhattacharyya A
DOI：
10.1016/j.jcmgh.2016.12.003
发表时间：
2017-03
影响因子：
7.2
作者：
Boland CR;Yurgelun MB
通讯作者：
Yurgelun MB
影响因子：
2.5
作者：
Choi IJ
通讯作者：
Choi IJ
影响因子：
3.8
作者：
Corso G;Marrelli D;Pascale V;Vindigni C;Roviello F
通讯作者：
Roviello F