Involvement of the renin-angiotensin system in the progression of severe hand-foot-and-mouth disease.
Involvement of the renin-angiotensin system in the progression of severe hand-foot-and-mouth disease.
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肾素-血管紧张素系统参与严重手足口病的进展。
DOI：
10.1371/journal.pone.0197861
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Duan G
中科院分区：
文献类型：
--
作者：
Zhang C;Chen S;Zhou G;Jin Y;Zhang R;Yang H;Xi Y;Ren J;Duan G
手足口病（Hand-foot-and-mouth disease，HFMD）是一种世界范围内危害婴幼儿的轻症外展性疾病。手足口病通常是轻微和自限性的，但少数病例会导致复杂的严重临床结果，甚至死亡。既往研究表明，H7N9感染患者血清Ang II水平与感染严重程度相关。然而，重症手足口病的发病机制仍不清楚。本研究旨在阐明肾素-血管紧张素系统（RAS）在重症手足口病进展中的作用。在本研究中，招募了162名儿童，包括手足口病患者和健康对照。数据采用时间序列分析。采用酶联免疫吸附法（ELISA）测定患者血清中血管紧张素II（Ang II）和去甲肾上腺素（NA）的浓度。我们建立了肠道病毒71（EV 71）感染小鼠模型，并在感染后3、5和7天（dpi）测定了组织裂解物中Ang II、NA的浓度。轻、重度手足口病患者血清中Ang Ⅱ和NA浓度均显著高于健康对照组。重症组血清中Ang Ⅱ和NA浓度均显著高于轻症组，且在病程进展过程中Ang Ⅱ和NA浓度升高趋势一致。此外，在EV 71感染小鼠的靶器官（包括脑、骨骼肌和肺）中，Ang II和NA的浓度随着EV 71感染小鼠的进展而增加。在EV 71感染小鼠的脑、骨骼肌和肺中观察到组织学改变。我们的研究表明RAS的激活与重症手足口病的发病机制有关。
Hand-foot-and-mouth disease (HFMD) is generally considered as a mild exanthematous disease to infants and young children worldwide. HFMD cases are usually mild and self-limiting but for few cases leads to complicated severe clinical outcomes, and even death. Previous studies have indicated that serum Ang II levels in patients with H7N9 infection were related to the severity of infection. However, the mechanisms underlying the pathogenesis of severe HFMD remain unclear. This study was undertaken to clarify the role of the renin-angiotensin system (RAS) in the progression of severe HFMD. In the present study, 162 children including HFMD patients and healthy controls were recruited. The data was analyzed by time-series fashion. Concentrations of angiotensin II (Ang II) and noradrenaline (NA) in serum of patients were measured with ELISA. We established a mouse model for enterovirus 71 (EV71) infection and determined concentrations of Ang II, NA in tissue lysates at 3, 5 and 7 days post infection (dpi). The concentrations of Ang II and NA in serum of the HFMD patients with mild or severe symptoms were significantly higher than that in healthy controls. Additionally, the concentrations of Ang II and NA in serum of severe cases were significantly higher than those mild cases and the increased concentrations of Ang II and NA showed the same time trend during the progression of HFMD in the severe cases. Furthermore, the concentrations of Ang II and NA in target organs of EV71-infected mice including brains, skeletal muscle, and lungs were increased with the progression of EV71 infection in mice. Histopathological alterations were observed in the brains, skeletal muscle and lungs of EV71-infected mice. Our study suggested that activation of the RAS is implicated in the pathogenesis of severe HFMD.
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影响因子：
7.1
作者：
Yamamura H;Kawazoe Y;Miyamoto K;Yamamoto T;Ohta Y;Morimoto T
通讯作者：
Morimoto T
影响因子：
5.1
作者：
RICHARDSON, HB;LEIBOVITZ, A
通讯作者：
LEIBOVITZ, A
DOI：
10.1097/nen.0b013e31817713e7
发表时间：
2008-06-01
影响因子：
3.2
作者：
Ong, Kien Chai;Badmanathan, Munisamy;Wong, Kum Thong
通讯作者：
Wong, Kum Thong
血管紧张素转换酶 2 可预防致命的甲型禽流感 H5N1 感染
影响因子：
16.6
作者：
Zou Z;Yan Y;Shu Y;Gao R;Sun Y;Li X;Ju X;Liang Z;Liu Q;Zhao Y;Guo F;Bai T;Han Z;Zhu J;Zhou H;Huang F;Li C;Lu H;Li N;Li D;Jin N;Penninger JM;Jiang C
通讯作者：
Jiang C
影响因子：
82.9
作者：
Kuba K;Imai Y;Rao S;Gao H;Guo F;Guan B;Huan Y;Yang P;Zhang Y;Deng W;Bao L;Zhang B;Liu G;Wang Z;Chappell M;Liu Y;Zheng D;Leibbrandt A;Wada T;Slutsky AS;Liu D;Qin C;Jiang C;Penninger JM
通讯作者：
Penninger JM