A mixed-effects model approach for estimating the distribution of usual intake of nutrients: the NCI method.
A mixed-effects model approach for estimating the distribution of usual intake of nutrients: the NCI method.
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DOI：
10.1002/sim.4063
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发表时间：
2010-11-30
影响因子：
2
通讯作者：
Dodd, Kevin W.
中科院分区：
文献类型：
--
作者：
Tooze, Janet A.;Kipnis, Victor;Buckman, Dennis W.;Carroll, Raymond J.;Freedman, Laurence S.;Guenther, Patricia M.;Krebs-Smith, Susan M.;Subar, Amy F.;Dodd, Kevin W.
关键词：
通过重复24小时膳食回忆评估来估计人群的日常营养素摄入量分布是有意义的。在国家癌症研究所（NCI）开发的混合效应模型和分位数估计程序可用于此目的。该模型采用Box-Cox参数和协变量来估计日常营养素摄入量;模型参数通过自适应高斯积分近似似然的拟牛顿优化来估计。在蒙特卡洛方法中使用参数估计值生成经验分位数;通过自助法估计标准误。NCI的方法进行说明，并与目前的估计方法，包括个人的平均值和半参数的方法，在爱荷华州州立大学（ISU），使用随机样本和计算机模拟的数据。营养素的NCI和ISU方法均上级单个平均值的分布。对于简单（无协变量）模型，分位数估计值在NCI和ISU方法之间相似。NCI方法估计分位数标准误差的自助法似乎优于泰勒线性化。NCI方法的一个主要优点是它能够通过将协变量纳入模型来提供亚群的估计值。NCI方法可用于估计人群和亚人群的通常营养素摄入量分布，作为估计膳食成分通常摄入量的统一框架的一部分。
It is of interest to estimate the distribution of usual nutrient intake for a population from repeat 24-h dietary recall assessments. A mixed effects model and quantile estimation procedure, developed at the National Cancer Institute (NCI), may be used for this purpose. The model incorporates a Box–Cox parameter and covariates to estimate usual daily intake of nutrients; model parameters are estimated via quasi-Newton optimization of a likelihood approximated by the adaptive Gaussian quadrature. The parameter estimates are used in a Monte Carlo approach to generate empirical quantiles; standard errors are estimated by bootstrap. The NCI method is illustrated and compared with current estimation methods, including the individual mean and the semi-parametric method developed at the Iowa State University (ISU), using data from a random sample and computer simulations. Both the NCI and ISU methods for nutrients are superior to the distribution of individual means. For simple (no covariate) models, quantile estimates are similar between the NCI and ISU methods. The bootstrap approach used by the NCI method to estimate standard errors of quantiles appears preferable to Taylor linearization. One major advantage of the NCI method is its ability to provide estimates for subpopulations through the incorporation of covariates into the model. The NCI method may be used for estimating the distribution of usual nutrient intake for populations and subpopulations as part of a unified framework of estimation of usual intake of dietary constituents.
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影响因子：
4.2
作者：
Woteki, CE
通讯作者：
Woteki, CE
影响因子：
4.2
作者：
Guenther, PM;Kott, PS;Carriquiry, AL
通讯作者：
Carriquiry, AL
影响因子：
3.7
作者：
Nusser, SM;Carriquiry, AL;Fuller, WA
通讯作者：
Fuller, WA
影响因子：
4.2
作者：
Freedman, LS;Midthune, D;Kipnis, V
通讯作者：
Kipnis, V
影响因子：
5
作者：
Kipnis, V;Subar, AF;Carroll, RJ
通讯作者：
Carroll, RJ