Relationship between Myocardial Flow Reserve by Oxygen-15 Water Positron Emission Tomography in the Subacute Phase of Myocardial Infarction and Left Ventricular Remodeling in the Chronic Phase
Relationship between Myocardial Flow Reserve by Oxygen-15 Water Positron Emission Tomography in the Subacute Phase of Myocardial Infarction and Left Ventricular Remodeling in the Chronic Phase
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心肌梗死亚急性期氧15水正电子发射断层扫描心肌血流储备与慢性期左心室重构的关系
DOI：
10.1291/hypres.31.1307
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发表时间：
2008
影响因子：
5.4
通讯作者：
M. Kohno
中科院分区：
文献类型：
--
作者：
Minako Ohara;K. Yukiiri;H. Masugata;Y. Iwado;H. Takinami;Y. Nishiyama;M. Ohkawa;S. Senda;K. Ohmori;M. Kohno
本研究旨在应用氧-15正电子发射断层扫描（PET）技术，观察血管紧张素转换酶抑制剂（ACEI）或血管紧张素受体阻滞剂（ARB）对急性心肌梗死（AMI）患者亚急性期心肌血流储备的影响，并探讨慢性期心肌血流储备与重构的关系。入选60例AMI发病后12 h内接受冠状动脉成形术治疗的患者。患者分为依那普利（ACEI）组和坎地沙坦（ARB）组。采用氧-15水PET法测定AMI发病后20 ~ 30 d亚急性期心肌血流储备。在发病后约6个月的慢性期进行左心室造影以测量左心室射血分数。依那普利组有10名患者（33%）和坎地沙坦组有4名患者（13%）在开始治疗后几天内停止服用各自的药物，原因是咳嗽或低血压等副作用。因此，依那普利组的药物不耐受发生率较高。依那普利组亚急性期心肌血流储备（2.08±0.30）和慢性期左室射血分数（42±6%）低于坎地沙坦组（2.25±0.20和49±5%）（P<0.05）。心肌血流储备与左室射血分数呈显著正相关（r=0.45，P<0.01）。在AMI后亚急性期用PET评估的心肌血流储备被发现与慢性期的左室重构有关。
The purposes of this study were to examine the effects of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) on myocardial flow reserve in patients with acute myocardial infarction (AMI) in the subacute phase using oxygen-15 positron emission tomography (PET) and to elucidate the relationship between the myocardial flow reserve and remodeling in the chronic phase. Sixty patients who had been treated with coronary angioplasty within 12 h after the onset of AMI were enrolled. Patients were divided into an enalapril (ACEI) group and a candesartan (ARB) group. The myocardial flow reserve was measured by oxygen-15 water PET in the subacute phase from the 20th to the 30th day after the onset of AMI. Left ventriculography was performed to measure the left ventricular ejection fraction in the chronic phase about 6 months after the onset. Ten patients (33%) in the enalapril group and 4 patients (13%) in the candesartan group stopped taking their respective medications within a few days of starting, because of side effects such as cough or hypotension. Thus, the prevalence of medication intolerance was higher in the enalapril group. The myocardial flow reserve in the subacute phase and the left ventricular ejection fraction in the chronic phase were lower in the enalapril group (2.08±0.30 and 42±6%) than in the candesartan group (2.25±0.20 and 49±5%) (p<0.05). The myocardial flow reserve significantly correlated with the left ventricular ejection fraction in all patients (r=0.45, p<0.01). The myocardial flow reserve assessed by PET in the subacute phase after AMI was found to be related to left ventricular remodeling in the chronic phase.
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既往高血压患者心肌梗死后左心室重构。
DOI：
--
发表时间：
2005
期刊：
Hypertens Res. Apr;28(4)
影响因子：
--
作者：
Yoshiyama M;Kamimori K;Shimada Y;Omura T;Kino N;Iida H;Yoshikawa J
通讯作者：
Yoshikawa J
通过 15O-H2O 正电子发射断层扫描直接证明人类衰竭心脏中心肌血流储备的前负荷依赖性
影响因子：
0.6
作者：
H. Takinami;Y. Iwado;K. Ohmori;K. Mizushige;Yoshihiro Nisiyama;M. Okawa;C. Kato;N. Tamaki;S. Senda;M. Kohno
通讯作者：
M. Kohno
DOI：
--
发表时间：
2005-07
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
H. Watabe;H. Jino;N. Kawachi;N. Teramoto;Takuya Hayashi;Y. Ohta;H. Iida
通讯作者：
H. Watabe;H. Jino;N. Kawachi;N. Teramoto;Takuya Hayashi;Y. Ohta;H. Iida
影响因子：
158.5
作者：
Pfeffer, MA;McMurray, JJV;Trapani, A
通讯作者：
Trapani, A