Clinical use of lactate monitoring in critically ill patients.
Clinical use of lactate monitoring in critically ill patients.
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DOI：
10.1186/2110-5820-3-12
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发表时间：
2013-05-10
影响因子：
8.1
通讯作者：
Jansen TC
中科院分区：
文献类型：
--
作者：
Bakker J;Nijsten MW;Jansen TC
血乳酸水平升高（高乳酸血症）在危重病人中很常见。虽然经常用于诊断组织氧合不足，但其他与组织氧合无关的过程可能会增加乳酸水平。特别是危重病人，糖酵解增加可能是高乳酸血症的重要原因。然而，乳酸水平升高的存在对高乳酸血症患者的发病率和死亡率具有重要意义。虽然乳酸酸中毒这个术语经常被使用，但乳酸和pH值之间的显著关系只存在于较高的乳酸水平。因此，乳酸相关酸中毒一词更为合适。最近的两项研究强调了监测乳酸水平的重要性，并在早期复苏中根据乳酸水平的变化调整治疗。由于乳酸水平可以在床边从各种来源快速测量，因此应将结构化乳酸测量纳入复苏方案。
Increased blood lactate levels (hyperlactataemia) are common in critically ill patients. Although frequently used to diagnose inadequate tissue oxygenation, other processes not related to tissue oxygenation may increase lactate levels. Especially in critically ill patients, increased glycolysis may be an important cause of hyperlactataemia. Nevertheless, the presence of increased lactate levels has important implications for the morbidity and mortality of the hyperlactataemic patients. Although the term lactic acidosis is frequently used, a significant relationship between lactate and pH only exists at higher lactate levels. The term lactate associated acidosis is therefore more appropriate. Two recent studies have underscored the importance of monitoring lactate levels and adjust treatment to the change in lactate levels in early resuscitation. As lactate levels can be measured rapidly at the bedside from various sources, structured lactate measurements should be incorporated in resuscitation protocols.
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影响因子：
38.9
作者：
Friedman, G;De Backer, D;Vincent, JL
通讯作者：
Vincent, JL
DOI：
10.1186/cc3987
发表时间：
2006-02
期刊：
Critical care (London, England)
影响因子：
--
作者：
Gunnerson KJ;Saul M;He S;Kellum JA
通讯作者：
Kellum JA
影响因子：
38.9
作者：
Bollmann, MD;Revelly, JP;Chioléro, RL
通讯作者：
Chioléro, RL
影响因子：
3.8
作者：
Fauchère, JC;Bauschatz, AS;Bucher, HU
通讯作者：
Bucher, HU
影响因子：
8.8
作者：
ALMENOFF, PL;LEAVY, J;RACKOW, EC
通讯作者：
RACKOW, EC