Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders.
Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders.
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DOI：
10.1001/archgenpsychiatry.2009.115
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发表时间：
2009-09
影响因子：
--
通讯作者：
Small, Scott A.
中科院分区：
文献类型：
--
作者：
Schobel, Scott A.;Lewandowski, Nicole M.;Corcoran, Cheryl M.;Moore, Holly;Brown, Truman;Malaspina, Dolores;Small, Scott A.
由于精神分裂症和相关疾病有一个慢性的时间过程和微妙的组织病理学，很难确定哪些大脑区域是不同的目标。为了确定精神分裂症的差异靶向脑部位，我们对临床特征患者和匹配的健康对照组以及前瞻性随访的前驱受试者队列应用了功能磁共振成像的高分辨率变体。此外，为了探索药物使用的潜在混淆，将fMRI变体应用于接受抗精神病药物的啮齿动物。横断面和前瞻性队列设计。医院门诊和磁共振成像实验室。18例精神分裂症患者，18例年龄和性别相当的对照组，18例前驱期患者前瞻性随访2年。10只C57-B小鼠接受抗精神病药物或载体对照。局部脑血容量（CBV），用磁共振成像测量，症状严重程度，用临床评定量表测量。在第一组间分析，比较精神分裂症患者与对照组，结果显示异常CBV增加的CA 1子域和眶额皮质和异常CBV减少背外侧前额叶皮质。在第二个纵向分析中，基线CBV异常在CA 1子字段差异预测临床进展为精神病从前驱状态。在第三个相关性分析中，CBV水平在CA 1子域差异与精神病的临床症状。最后，对人类数据集和小鼠成像研究的额外分析表明，抗精神病药物不会混淆主要结果。作为一个整体，结果表明，海马子区的CA 1子域是精神分裂症和相关精神障碍的差异目标。在先前研究的背景下解释，这些发现告知疾病进展的潜在机制。
Because schizophrenia and related disorders have a chronic time course and subtle histopathology, it is difficult to identify which brain regions are differentially targeted. To identify brain sites differentially targeted by schizophrenia, we applied a high-resolution variant of functional magnetic resonance imaging to clinically characterized patients and matched healthy controls and to a cohort of prodromal subjects who were prospectively followed up. Additionally, to explore the potential confound of medication use, the fMRI variant was applied to rodents receiving an antipsychotic agent. Cross-sectional and prospective cohort designs. Hospital clinic and magnetic resonance imaging laboratory. Eighteen patients with schizophrenia, 18 controls comparable in age and sex, and 18 prodromal patients followed up prospectively for 2 years. Ten C57-B mice received an antipsychotic agent or vehicle control. Regional cerebral blood volume (CBV), as measured with magnetic resonance imaging, and symptom severity, as measured with clinical rating scales. In a first between-group analysis that compared patients with schizophrenia with controls, results revealed abnormal CBV increases in the CA1 subfield and the orbitofrontal cortex and abnormal CBV decreases in the dorsolateral prefrontal cortex. In a second longitudinal analysis, baseline CBV abnormalities in the CA1 subfield differentially predicted clinical progression to psychosis from a prodromal state. In a third correlational analysis, CBV levels in the CA1 subfield differentially correlated with clinical symptoms of psychosis. Finally, additional analyses of the human data set and imaging studies in mice suggested that antipsychotic agents were not confounding the primary findings. Taken as a whole, the results suggest that the CA1 subfield of the hippocampal subregion is differentially targeted by schizophrenia and related psychotic disorders. Interpreted in the context of previous studies, these findings inform underlying mechanisms of illness progression.
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DOI：
10.1523/jneurosci.1815-08.2008
发表时间：
2008-07-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Chen YJ;Johnson MA;Lieberman MD;Goodchild RE;Schobel S;Lewandowski N;Rosoklija G;Liu RC;Gingrich JA;Small S;Moore H;Dwork AJ;Talmage DA;Role LW
通讯作者：
Role LW
影响因子：
10.6
作者：
Benes, FM
通讯作者：
Benes, FM
影响因子：
8.3
作者：
GRUBB, RL;RAICHLE, ME;TERPOGOS.MM
通讯作者：
TERPOGOS.MM
影响因子：
4.8
作者：
Brambilla, Paolo;Cerini, Roberto;Tansella, Michele
通讯作者：
Tansella, Michele
DOI：
10.1073/pnas.0806669105
发表时间：
2008-11-18
影响因子：
11.1
作者：
Homayoun, Hournan;Moghaddam, Bita
通讯作者：
Moghaddam, Bita