Tumor-homing peptide and its utility for advanced cancer medicine.
Tumor-homing peptide and its utility for advanced cancer medicine.
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DOI：
10.1111/cas.14909
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发表时间：
2021-06
期刊：
影响因子：
5.7
通讯作者：
Saito K
中科院分区：
文献类型：
--
作者：
Kondo E;Iioka H;Saito K
细胞穿透性多肽，如抗体，作为开发有效载荷的特定递送系统的工具，在体内可能作为非侵入性载体而受到极大的关注。其中，肿瘤归巢多肽最近已被研究用于肿瘤药物。肿瘤归巢多肽是一种寡肽，通常由30个或更少的氨基酸组成，可以有效和特异地结合到肿瘤细胞中，这表明它们在建立新型非侵入性肿瘤成像系统方面具有潜在的诊断和治疗应用。在这里，我们简要介绍我们的肿瘤归宿多肽的生物学特性，特别是那些利用mRNA展示技术构建的随机多肽文库开发的多肽。肿瘤归宿多肽的优势在于它们的生物安全性，因为这些分子对非肿瘤细胞没有明显的细胞毒性；缺乏严重的抗原性，这可能会在体内引发不利的免疫反应和炎症；并迅速结合到靶细胞/组织中，其结合速度超过抗体。由于其体积小，肿瘤归宿多肽也很容易修改和重新设计。基于这些优点，肿瘤归巢多肽有望在肿瘤医学的各个方面得到广泛的应用，包括成像诊断(例如，与染料标记的探针一起直接显示体内的肿瘤侵袭/转移病变)和治疗(例如，使用多肽-药物结合物[PDCs]进行肿瘤靶向)。虽然还需要更多的证据来证明它们的实用价值，但肿瘤归宿多肽有望作为下一代生物工具显示出巨大的潜力，有助于癌症患者的精确医学。介绍肿瘤归巢多肽，重点介绍其生化特性及其在晚期癌症药物中的应用。
Cell‐penetrating peptides, such as antibodies, have gained great attention as tools for the development of specific delivery systems for payloads, which might be applied as non‐invasive carriers in vivo. Among these, tumor‐homing peptides recently have been studied for use in tumor medicine. Tumor‐homing peptides are oligopeptides, usually consisting of 30 or fewer amino acids that are efficiently and specifically incorporated into tumor cells, suggesting their potential use in establishing novel non‐invasive tumor imaging systems for diagnostic and therapeutic applications. Here, we briefly introduce the biological characteristics of our tumor‐homing peptides, focusing especially on those developed using a random peptide library constructed using mRNA display technology. The advantage of the tumor‐homing peptides is their biological safety, given that these molecules do not show significant cytotoxicity against non‐neoplastic cells; lack serious antigenicity, which alternatively might evoke unfavorable immune responses and inflammation in vivo; and are rapidly incorporated into target cells/tissues, with rates exceeding those seen for antibodies. Given their small size, tumor‐homing peptides also are easy to modify and redesign. Based on these merits, tumor‐homing peptides are expected to find wide application in various aspects of tumor medicine, including imaging diagnostics (eg, with dye‐conjugated probes for direct visualization of invasive/metastatic tumor lesions in vivo) and therapeutics (eg, using peptide‐drug conjugates [PDCs] for tumor targeting). Although further evidence will be required to demonstrate their practical utility, tumor‐homing peptides are expected to show great potential as a next‐generation bio‐tool contributing to precision medicine for cancer patients. Introduction of tumor‐homing peptides focusing on their biochemical characteristics and their use in advanced cancer medicine.
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影响因子：
56.9
作者：
Schwarze, SR;Ho, A;Dowdy, SF
通讯作者：
Dowdy, SF
影响因子：
5.7
作者：
Saito K;Iioka H;Kojima C;Ogawa M;Kondo E
通讯作者：
Kondo E
影响因子：
3.9
作者：
Futaki, S.;Nakase, I.;Jones, A. T.
通讯作者：
Jones, A. T.
影响因子：
5.4
作者：
Kamide, Kaeko;Nakakubo, Hiroshi;Fukamizu, Akiyoshi
通讯作者：
Fukamizu, Akiyoshi
影响因子：
5.7
作者：
Sugahara KN;Braun GB;de Mendoza TH;Kotamraju VR;French RP;Lowy AM;Teesalu T;Ruoslahti E
通讯作者：
Ruoslahti E