Cytological Appearances of Ovarian Seromucinous Borderline Tumor in Ascites: Presentation of 2 Cases
Cytological Appearances of Ovarian Seromucinous Borderline Tumor in Ascites: Presentation of 2 Cases
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腹水中卵巢浆液粘液性交界性肿瘤的细胞学表现：附2例报告
DOI：
10.1159/000517313
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发表时间：
2021
期刊：
影响因子：
1.8
通讯作者：
Aishima Shinichi
中科院分区：
文献类型：
--
作者：
Kai Keita;Hashiguchi Mariko;Kurihara Makiko;Tanaka Yuya;Kitamura Sho;Nakamura Mitsuo;Shichijo Chika;Yamamoto-Rikitake Mihoko;Okuma Ryoichi;Hikari Takako;Okuma Emi;Uchiyama Michiko;Aoki Shigehisa;Nakao Yoshifumi;Yokoyama Masatoshi;Aishima Shinichi
研究背景浆液粘液性交界性肿瘤（SMBT）是2014年WHO分类中新定义的一种罕见肿瘤。尽管 SMBT 的临床和组织病理学特征已得到很好的描述，但其细胞学特征尚未得到充分描述。我们最近经历了 2 例 SMBT 病例，其定义是腹水细胞学结果。病例介绍病例 1 是一名 65 岁的日本女性。术前影像学检查显示大量腹水和囊性肿瘤，左侧卵巢上有一个 13 厘米的实性成分。术中诊断卵巢交界性肿瘤时，通过冰冻肿瘤切片的组织学检查进行根治性手术。术前和术中收集的腹水细胞学涂片显示许多类似反应性间皮细胞的非典型细胞。细胞块切片阿尔新蓝染色显示胞浆内粘蛋白，免疫组化结果与SMBT一致。最终病理诊断肿瘤为SMBT。病例2是一名28岁的日本女性。术前影像学检查显示双侧卵巢有少量腹水和囊性肿瘤，伴实性成分。她最初接受了生育力保留手术。通过术中收集的腹水涂片的细胞学检查和细胞块的发现来怀疑SMBT。根据最终的 SMBT 病理诊断，她接受了额外的根治性手术。结论根据我们的经验，腹水中的 SMBT 肿瘤细胞模仿了反应性间皮细胞。 SMBT 的核异型性介于反应性间皮细胞和浆液性癌之间。使用细胞块的免疫组织化学和粘蛋白染色对于促进SMBT的细胞诊断非常有帮助。
BackgroundSeromucinous borderline tumor (SMBT) is a rare neoplasm which was newly defined in the 2014 WHO classification. Although the clinical and histopathological characteristics of SMBT have been well described, its cytological characteristics have not. We recently experienced 2 cases of SMBT which were defined by cytological findings of ascites.Case PresentationCase 1 was a 65-year-old Japanese woman. Preoperative imaging studies revealed abundant ascites and a cystic tumor, with a solid component measuring 13 cm on the left ovary. Radical surgery was performed during the intraoperative diagnosis of ovarian borderline tumor, made by histological examinations of frozen tumor sections. The cytological smears of preoperatively and intraoperatively collected ascites showed many atypical cells resembling reactive mesothelial cells. Alcian-blue staining of cell block sections revealed intracytoplasmic mucin, and the results of immunohistochemistry were consistent with SMBT. The final pathological diagnosis of tumor was SMBT. Case 2 was a 28-year-old Japanese woman. Preoperative imaging studies revealed a small amount of ascites and cystic tumors with solid components in the bilateral ovaries. She initially underwent fertility preservation surgery. SMBT was suspected by cytological examination of smears of intraoperatively collected ascites and the findings of cell block. She underwent additional radical surgery based on a final pathological diagnosis of SMBT.ConclusionIn our experience, the tumor cells of SMBT in ascites mimicked reactive mesothelial cells. The nuclear atypia of SMBTs was intermediate between that of reactive mesothelial cells and serous carcinoma. The immunohistochemistry and mucin staining using cell block were very helpful for facilitating the cytodiagnosis of SMBT.
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DOI：
10.1016/j.jogoh.2020.101966
发表时间：
2021-01-15
影响因子：
1.9
作者：
Bourdel, Nicolas;Huchon, Cyrille;Darai, Emile
通讯作者：
Darai, Emile
DOI：
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发表时间：
2008
期刊：
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DOI：
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2005-04-01
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卵巢浆液粘液性（宫颈内膜型粘液性和混合细胞型）肿瘤的诊断标准和行为：非典型增殖性（交界性）肿瘤、上皮内癌、微侵袭性癌和侵袭性癌
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