The influence of paediatric HIV infection on circulating B cell subsets and CXCR5(+) T helper cells.
The influence of paediatric HIV infection on circulating B cell subsets and CXCR5(+) T helper cells.
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DOI：
10.1111/cei.12618
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发表时间：
2015-07
影响因子：
4.6
通讯作者：
Kampmann B
中科院分区：
文献类型：
--
作者：
Bamford A;Hart M;Lyall H;Goldblatt D;Kelleher P;Kampmann B
抗逆转录病毒治疗（ART）只能部分恢复HIV诱导的淋巴细胞群改变。我们评估了来自英国一个中心的围产期获得性HIV儿童队列与健康对照组的B和T细胞表型。大多数HIV感染儿童（56例中的44例）接受完全抑制性联合ART治疗。围产期获得性HIV儿童的记忆B和CD 4 + CD 45 RO + CXCR 5 + [滤泡性T辅助细胞（Tfh）样] T细胞百分比显著降低。可检测的病毒血症与较高的CD 21-（活化和耗竭/组织样记忆）B细胞相关。更大比例的生命花费在抑制性ART上与更高的记忆B细胞百分比相关。这些结果表明，早期和持续的抑制性ART可能会保留B和T细胞表型在围产期获得的艾滋病毒和限制体液免疫缺陷。HIV感染儿童中循环Tfh样细胞比例较低似乎与HIV治疗史和持续的HIV病毒血症无关，需要进一步研究。
Antiretroviral therapy (ART) only partially restores HIV‐induced alterations in lymphocyte populations. We assessed B and T cell phenotypes in a cohort of children from a single centre in the United Kingdom with perinatally acquired HIV compared to healthy controls. The majority of HIV infected children (44 of 56) were on fully suppressive combination ART. Children with perinatally acquired HIV had significantly lower memory B and CD4+CD45RO+CXCR5+ [follicular T helper cell (Tfh)‐like] T cell percentages. Detectable viraemia was associated with higher CD21– (activated and exhausted/tissue‐like memory) B cells. A greater proportion of life spent on suppressive ART was associated with higher memory B cell percentages. These results suggest that early and sustained suppressive ART may preserve B and T cell phenotypes in perinatally acquired HIV and limit deficits in humoral immunity. A lower proportion of circulating Tfh‐like cells in HIV infected children appears to be independent of HIV treatment history and ongoing HIV viraemia and warrants further investigation.
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DOI：
10.1097/qad.0b013e3283189bb3
发表时间：
2008-11-12
期刊：
AIDS (London, England)
影响因子：
--
作者：
Weinberg A;Dickover R;Britto P;Hu C;Patterson-Bartlett J;Kraimer J;Gutzman H;Shearer WT;Rathore M;McKinney R;PACTG 1021 team
通讯作者：
PACTG 1021 team
影响因子：
3
作者：
Bamford A;Turkova A;Lyall H;Foster C;Klein N;Bastiaans D;Burger D;Bernadi S;Butler K;Chiappini E;Clayden P;Della Negra M;Giacomet V;Giaquinto C;Gibb D;Galli L;Hainaut M;Koros M;Marques L;Nastouli E;Niehues T;Noguera-Julian A;Rojo P;Rudin C;Scherpbier HJ;Tudor-Williams G;Welch SB;(PENTA Steering Committee)
通讯作者：
(PENTA Steering Committee)
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1038/nri2524
发表时间：
2009-04
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.8
作者：
Bamford, Alasdair;Kelleher, Peter;Kampmann, Beate
通讯作者：
Kampmann, Beate