Immunohistochemical Studies on Matrix Metalloproteinase‐9 (MMP‐9) and Type‐IV Collagen in Endometrial Carcinoma
Immunohistochemical Studies on Matrix Metalloproteinase‐9 (MMP‐9) and Type‐IV Collagen in Endometrial Carcinoma
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子宫内膜癌中基质金属蛋白酶-9 (MMP-9) 和 IV 型胶原的免疫组织化学研究
DOI：
10.1111/j.1447-0756.1997.tb00822.x
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发表时间：
1997
影响因子：
1.6
通讯作者：
K. Noda
中科院分区：
文献类型：
--
作者：
Y. Inoue;K. Abe;Koushirou Obata;T. Yoshioka;G. Ohmura;K. Doh;Kaichiro Yamamoto;H. Hoshiai;K. Noda
在子宫内膜癌的石蜡切片上进行MMP-9和IV型胶原的免疫组织化学染色。129例子宫内膜癌的免疫组化染色中，19.0%的病例检测到MMP-9。MMP-9在有血管侵犯的病例中阳性率为30%，在无血管侵犯的病例中阳性率为12.7%（p < 0.05）。MMP-9在分化差、淋巴结转移的病例中多呈阳性表达，但仍未能达到统计学意义。MMP-9染色与疾病结局无关。我们不能明确MMP-9与肿瘤细胞侵袭和转移有关。在58例子宫内膜癌病例中研究了肿瘤间质边缘的IV型胶原沉积，其中观察到不同程度的破坏。原发性病变中的IV型胶原随着分化程度的降低而降低。即使在淋巴结转移病变中，IV型胶原也被染色，并且与原发性病变几乎一致。在原发性病变中，MMP-9染色与IV型胶原之间没有关系。这表明在子宫内膜癌中观察到的IV型胶原与肿瘤的分化比MMP-9的降解更相关。
Immunohistochemical staining of MMP‐9 and the type‐IV collagen was performed on paraffin sections of endometrial carcinoma. Immunostaining in 129 cases of endometrial cancer detected MMP‐9 in 19.0% of the cases. MMP‐9 positive was shown in 30% of the cases with vessel invasion, and in 12.7% of the cases without vessell invasion (p < 0.05). MMP‐9 showed positive in many cases with poor differentiation and lymph node metastasis, but still failed to achieve statistical significance. MMP‐9 staining did not correlate with disease outcomes. We can not clarify that MMP‐9 is associated with tumor‐cell invasion and metastasis. Type‐IV collagen deposition at the tumor‐stromal border was studied in 58 cases of endometrial carcinoma in which disruptions were seen in varying degrees. The type‐IV collagen in the primary lesion decreased as the differentiation decreased. Even in the lymph node metastasis lesions, the type‐IV collagen was stained and was almost in agreement with the primary lesions. In the primary lesions, there was no relationship between MMP‐9 staining and the type‐IV collagen. It was suggested that the type‐IV collagen observed in endometrial carcinoma was more concerned with the differentiation of the tumor than with the degradation by MMP‐9.
影响因子：
11.2
作者：
M. Nakajima;D. Welch;P. Belloni;G. Nicolson
通讯作者：
M. Nakajima;D. Welch;P. Belloni;G. Nicolson
微管中 GTP 水解伴随的结构变化：来自缓慢水解类似物鸟苷基-(α,β)-亚甲基二膦酸酯的信息。
DOI：
10.1083/jcb.128.1.117
发表时间：
1995-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Hyman AA;Chrétien D;Arnal I;Wade RH
通讯作者：
Wade RH