Prognostic Role of Combined EGFR and Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma.
Prognostic Role of Combined EGFR and Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma.
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DOI：
10.3389/fonc.2022.885236
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发表时间：
2022
影响因子：
4.7
通讯作者：
Simons, Andrean L.
中科院分区：
文献类型：
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作者：
Wongpattaraworakul, Wattawan;Gibson-Corley, Katherine N.;Choi, Allen;Buchakjian, Marisa R.;Lanzel, Emily A.;Rajan, K. D. Anand;Simons, Andrean L.
表皮生长因子受体（epidermalgrowthfactorreceptor，EGFR）是头颈部肿瘤的一种常用的预后指标，但其在口腔鳞状细胞癌（oralsquamouscellcarcinoma，OSCC）中的特异性预后价值仍存在争议。最近，肿瘤浸润性T细胞的存在与各种疾病部位的显著生存优势相关。本研究将确定纳入T细胞特异性标志物（CD 3、CD 4和CD 8）是否会增强EGFR在OSCC中的预后价值。采用免疫组织化学方法检测146例口腔鳞癌组织芯片中EGFR、CD 3、CD 4和CD 8的表达。EGFR和T细胞表达评分与临床病理参数和生存结局相关。结果显示，EGFR表达对总生存期（OS）没有影响，但EGFR阳性（EGFR+）OSCC患者的无进展生存期（PFS）显著低于EGFR阴性（EGFR-）患者。CD 3、CD 4和CD 8阳性肿瘤患者的OS分别显著优于CD 3、CD 4和CD 8阴性患者，但对PFS无影响。与EGFR+/CD 3-表达相比，EGFR+/CD 3+联合表达与无淋巴结受累的病例相关，OS显著更有利。CD 3表达对EGFR-患者的OS或PFS无影响。EGFR/CD 8和EGFR/CD 4表达的组合显示，表达组之间的OS或PFS无显著差异。总之，这些结果表明，CD 3+肿瘤浸润性T细胞的表达可以提高EGFR表达的预后价值，并值得进一步研究作为OSCC的预后生物标志物。
Epidermal growth factor receptor (EGFR) is well known as a general prognostic biomarker for head and neck tumors, however the specific prognostic value of EGFR in oral squamous cell carcinoma (OSCC) is controversial. Recently, the presence of tumor-infiltrating T cells has been associated with significant survival advantages in a variety of disease sites. The present study will determine if the inclusion of T cell specific markers (CD3, CD4 and CD8) would enhance the prognostic value of EGFR in OSCCs. Tissue microarrays containing 146 OSCC cases were analyzed for EGFR, CD3, CD4 and CD8 expression using immunohistochemical staining. EGFR and T cell expression scores were correlated with clinicopathological parameters and survival outcomes. Results showed that EGFR expression had no impact on overall survival (OS), but EGFR-positive (EGFR+) OSCC patients demonstrated significantly worse progression free survival (PFS) compared to EGFR-negative (EGFR-) patients. Patients with CD3, CD4 and CD8-positive tumors had significantly better OS compared to CD3, CD4 and CD8-negative patients respectively, but no impact on PFS. Combined EGFR+/CD3+ expression was associated with cases with no nodal involvement and significantly more favorable OS compared to EGFR+/CD3- expression. CD3 expression had no impact on OS or PFS in EGFR- patients. Combinations of EGFR/CD8 and EGFR/CD4 expression showed no significant differences in OS or PFS among the expression groups. Altogether these results suggest that the expression of CD3+ tumor-infiltrating T cells can enhance the prognostic value of EGFR expression and warrants further investigation as prognostic biomarkers for OSCC.
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影响因子：
4.7
作者：
Lequerica-Fernández P;Suárez-Canto J;Rodriguez-Santamarta T;Rodrigo JP;Suárez-Sánchez FJ;Blanco-Lorenzo V;Domínguez-Iglesias F;García-Pedrero JM;de Vicente JC
通讯作者：
de Vicente JC
影响因子：
4.7
作者：
Argiris A;Harrington KJ;Tahara M;Schulten J;Chomette P;Ferreira Castro A;Licitra L
通讯作者：
Licitra L
影响因子：
8.8
作者：
Balermpas, P;Michel, Y;Wagenblast, J;Seitz, O;Weiss, C;Rodel, F;Rodel, C;Fokas, E
通讯作者：
Fokas, E
影响因子：
11.5
作者：
Badoual, C;Hans, S;Tartour, E
通讯作者：
Tartour, E
DOI：
10.1159/000367959
发表时间：
2015-01-01
期刊：
ACTINIC KERATOSIS
影响因子：
--
作者：
Joseph, Shannon R.;Endo-Munoz, Liliana;Simpson, Fiona
通讯作者：
Simpson, Fiona