Stem Cell Therapy for Pediatric Traumatic Brain Injury.
Stem Cell Therapy for Pediatric Traumatic Brain Injury.
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干细胞疗法治疗小儿创伤性脑损伤。
DOI：
10.3389/fneur.2020.601286
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发表时间：
2020
影响因子：
3.4
通讯作者：
Raghupathi R
中科院分区：
文献类型：
--
作者：
Lengel D;Sevilla C;Romm ZL;Huh JW;Raghupathi R
干细胞移植治疗小儿脑损伤的潜力越来越受到关注。对创伤性脑损伤（TBI）和新生儿缺氧缺血（HI）等小儿脑损伤临床前模型的研究有助于我们了解内源性干细胞在脑损伤后修复过程和功能恢复中的作用，以及外源性干细胞移植对脑损伤恢复的影响。虽然只有少数研究已经评估了儿科TBI模型中的这些效果，但许多研究已经评估了新生儿HI模型中的干细胞移植治疗，新生儿HI与儿科TBI的损伤病理学有相当大的重叠。在这篇综述中，我们总结了在小儿脑损伤模型中干细胞治疗对组织病理学和功能结局影响的数据。重要的是，我们已经概述了支持干细胞移植缓解儿科TBI病理学（包括神经炎症和白色损伤）的潜力的证据，以及需要解决的挑战，以结合这些治疗来改善儿科TBI后的功能结局。
There has been a growing interest in the potential of stem cell transplantation as therapy for pediatric brain injuries. Studies in pre-clinical models of pediatric brain injury such as Traumatic Brain Injury (TBI) and neonatal hypoxia-ischemia (HI) have contributed to our understanding of the roles of endogenous stem cells in repair processes and functional recovery following brain injury, and the effects of exogenous stem cell transplantation on recovery from brain injury. Although only a handful of studies have evaluated these effects in models of pediatric TBI, many studies have evaluated stem cell transplantation therapy in models of neonatal HI which has a considerable overlap of injury pathology with pediatric TBI. In this review, we have summarized data on the effects of stem cell treatments on histopathological and functional outcomes in models of pediatric brain injury. Importantly, we have outlined evidence supporting the potential for stem cell transplantation to mitigate pathology of pediatric TBI including neuroinflammation and white matter injury, and challenges that will need to be addressed to incorporate these therapies to improve functional outcomes following pediatric TBI.
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影响因子：
4.2
作者：
Adelson, PD;Jenkins, LW;Kochanek, PM
通讯作者：
Kochanek, PM
影响因子：
0.7
作者：
Anderson, V;Catroppa, C;Rosenfeld, J
通讯作者：
Rosenfeld, J
影响因子：
1.2
作者：
Ara, Jahan;De Montpellier, Sybille
通讯作者：
De Montpellier, Sybille
影响因子：
3.7
作者：
Acosta, Sandra A.;Tajiri, Naoki;Borlongan, Cesar V.
通讯作者：
Borlongan, Cesar V.
DOI：
10.1016/j.ijdevneu.2010.12.003
发表时间：
2011-04-01
影响因子：
1.8
作者：
Beauchamp, M. H.;Ditchfield, M.;Anderson, V. A.
通讯作者：
Anderson, V. A.