Effects of restricted calcium intake on bone and maxillofacial growth.
Effects of restricted calcium intake on bone and maxillofacial growth.
复制标题
限制钙摄入量对骨骼和颌面生长的影响。
作者：
Koji Watanabe;H. Imamura;Shinsaku Uchikanbori;Y. Fujita;K. Maki
目的
通过测定生长期大鼠下牙槽骨、股骨和胫骨的骨矿物质含量（BMC）和进行头影测量，研究低钙饮食对颌面发育的影响。
材料和方法
30只5周龄雄性Wistar大鼠随机分为3组。对照组（n = 10）给予标准饮食6周，低钙/标准饮食组（n = 10）前4周给予限钙饮食，后2周给予标准饮食，低钙饮食组（n = 10）给予限钙饮食6周。对大鼠实施安乐死后，固定头部和腿部，并进行头影测量。接下来，对下颌骨、股骨和胫骨进行数码拍照，并使用我们新开发的软件对BMC进行评估。
结果
在接受限制钙的两组的所有骨样本中，BMC均降低。在低钙/标准饮食组中，胫骨BMC恢复最多，下牙槽骨BMC恢复最少。下颌骨前后方向的发育加快，上下方向的发育受到抑制。
结论
下牙槽骨缺钙后BMC减少很难恢复，因此预防很重要。由于钙限制饮食，上下方向的下颌骨发育受到抑制，而前后方向的下颌骨发育则加速。
OBJECTIVE
To investigate the effects of a low calcium diet on maxillofacial development by evaluating Bone Mineral Content (BMC) in the lower alveolar bones, femurs, and tibias and by performing cephalometry on growing rats.
MATERIALS AND METHODS
Thirty 5-week-old male Wistar rats were randomly divided into 3 groups; the control group (n = 10) was given standard diet for 6 weeks, the low calcium/standard diet group (n = 10) was given a calcium-restricted diet for the first 4 weeks, and then a standard diet for the following 2 weeks, and the low calcium diet group (n = 10) was given the calcium-restricted diet for 6 weeks. After the rats were euthanized, heads and legs were fixed and cephalometry was performed. Next, mandibles, femurs and tibias were digitally photographed and the BMC was evaluated using our newly developed software.
RESULTS
The BMC was decreased in all of the bone samples from the two groups that received restricted calcium. In the low calcium/standard diet group, the BMC recovered the most in the tibias and least in the lower alveolar bones. Development of the mandibles in the anterior-posterior direction was accelerated, while that in the superior-inferior direction was inhibited in those rats.
CONCLUSION
The BMC reduction following calcium deficiency in the lower alveolar bone hardly recovers, so prevention is important. Development of the mandible in a superior-inferior direction is inhibited while that in an anterior-posterior direction is accelerated due to a calcium-restricted diet.
生长激素缺乏大鼠的颅面生长。
DOI：
10.1002/ar.a.20051
发表时间：
2004
期刊：
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology
影响因子：
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作者：
Vandeberg,JamesR;Buschang,PeterH;Hinton,RobertJ
通讯作者：
Hinton,RobertJ