Effects of advanced life support versus basic life support on the mortality rates of patients with trauma in prehospital settings: a study protocol for a systematic review and meta-analysis.
Effects of advanced life support versus basic life support on the mortality rates of patients with trauma in prehospital settings: a study protocol for a systematic review and meta-analysis.
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DOI：
10.1136/bmjopen-2017-016912
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发表时间：
2017-10-22
期刊：
影响因子：
2.9
通讯作者：
Hayashida K
中科院分区：
文献类型：
--
作者：
Kondo Y;Fukuda T;Uchimido R;Hifumi T;Hayashida K
与基本生命支持 (BLS) 相比，高级生命支持 (ALS) 被认为与院前创伤护理中生存率的提高有关。然而，关于院前 ALS 对创伤患者的益处的证据存在争议。因此，我们的目的是通过对最近的文献进行系统回顾和荟萃分析，阐明与 BLS 相比，ALS 是否可以提高创伤患者的死亡率。我们将在 PubMed、Embase 和 Cochrane 对照试验中央注册库中检索已发表的观察性研究、前后对照研究、随机对照试验和其他在人体中进行并在 2017 年 3 月之前发表的对照试验。我们将筛选检索结果、评估研究选择、提取数据并评估一式两份的偏倚风险；分歧将通过讨论解决。来自临床同质研究的数据将使用随机效应荟萃分析进行汇总，效应的异质性将使用同质性的 χ2 检验进行评估，任何观察到的异质性将使用 I2 统计量进行量化。最后，将使用建议评估、制定和评估分级方法来评估证据的质量。我们的研究不需要伦理批准，因为它是基于之前发表的文章的发现。结果将通过在同行评审的期刊上发表、在相关会议上的演讲以及患者信息出版物来传播。 PROSPERO（国际系统评价前瞻性登记册）注册号 CRD42017054389。
Advanced life support (ALS) is thought to be associated with improved survival in prehospital trauma care when compared with basic life support (BLS). However, evidence on the benefits of prehospital ALS for patients with trauma is controversial. Therefore, we aim to clarify if ALS improves mortality in patients with trauma when compared with BLS by conducting a systematic review and meta-analysis of the recent literature. We will perform searches in PubMed, Embase and the Cochrane Central Register of Controlled Trials for published observational studies, controlled before-and-after studies, randomised controlled trials and other controlled trials conducted in humans and published until March 2017. We will screen search results, assess study selection, extract data and assess the risk of bias in duplicate; disagreements will be resolved through discussions. Data from clinically homogeneous studies will be pooled using a random-effects meta-analysis, heterogeneity of effects will be assessed using the χ2 test of homogeneity, and any observed heterogeneity will be quantified using the I2 statistic. Last, the Grading of Recommendations Assessment, Development and Evaluation approach will be used to rate the quality of the evidence. Our study does not require ethical approval as it is based on findings of previously published articles. Results will be disseminated through publication in a peer-reviewed journal, presentations at relevant conferences and publications for patient information. PROSPERO (International Prospective Register of Systematic Reviews) registration number CRD42017054389.
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影响因子：
7
作者：
Huedo-Medina, Tania B.;Sanchez-Meca, Julio;Botella, Juan
通讯作者：
Botella, Juan
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
3.1
作者：
Carrico, CJ;Holcomb, JB;Chaudry, IH
通讯作者：
Chaudry, IH
影响因子：
120.7
作者：
Hasegawa, Kohei;Hiraide, Atsushi;Brown, David F. M.
通讯作者：
Brown, David F. M.
DOI：
10.1097/00005373-200010000-00003
发表时间：
2000-10-01
影响因子：
--
作者：
Liberman, M;Mulder, D;Sampalis, J
通讯作者：
Sampalis, J