Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects.
Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects.
复制标题
DOI：
10.1016/j.cccb.2020.100002
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Wardlaw J
中科院分区：
文献类型：
--
作者：
Ballerini L;McGrory S;Valdés Hernández MDC;Lovreglio R;Pellegrini E;MacGillivray T;Muñoz Maniega S;Henderson R;Taylor A;Bastin ME;Doubal F;Trucco E;Deary IJ;Wardlaw J
血管周围间隙(PVS)的定量测量与大样本老年受试者(n=1381)的视网膜血管变化有关。PVS负荷越高，视网膜小动脉越细，分维越小。视网膜的分维可能是脑血管系统健康状况的一个指标。随着年龄的增长，血管周围间隙(PVS)在脑MRI上变得越来越明显，但它们与潜在微血管形态变化的关系仍然知之甚少。视网膜和大脑的微血管具有相同的形态和生理特性。我们比较了计算得出的PVS形态与老年人的视网膜血管形态。我们分析了平均年龄为72.55岁(SD=0.71)的社区居民的数据，他们接受了多模式脑MRI和视网膜眼底相机成像。我们通过计算评估半卵圆中心的PVS，以确定PVS的总体积和数量，以及每个受试者单个PVS的平均长度、宽度和大小。我们使用吸血鬼软件套件对视网膜图像进行分析，获得双眼视网膜中央动、静脉的等价物(CRVE和CRAE)、小动脉与小静脉的比率(AVR)和分维(FD)。我们使用一般线性模型研究了相关性，并根据年龄、性别和主要血管危险因素进行了调整。在所有测量的381名受试者中，PVS总体积和数目的增加与左眼CRAE的减少相关(体积β=−为0.170，β=−计数为0.184，p<；0.001)。未发现PVS与CRVE相关。PVS的总体积、个体宽度和大小随着左眼小动脉(A)和小静脉(V)FD的减小而增加(总体积：fdaβ=−0.137，fdvβ=−0.139；宽度：fdaβ=−0.144，fdvβ=−0.158，p<；0.01；大小：fdaβ=−0.157，fdvβ=−0.162，p<；0.01)。MRI上可见的PVS数量和大小的增加反映了微动脉狭窄和视网膜小动脉和小静脉分支复杂性的降低，这两个指标都是微血管健康受损的标志。计算得出的PVS指标可能是血管健康状况恶化的早期指标，应该在纵向研究中进行测试。
Quantitative measurements of Perivascular Spaces (PVS) relates to retinal vascular changes in a large sample of elderly subjects (n = 381). Higher PVS burden corresponds with narrower retinal arterioles and reduced fractal dimension. The retinal fractal dimension is a possible indicator of the state of health of the brain vasculature. Perivascular Spaces (PVS) become increasingly visible with advancing age on brain MRI, yet their relationship to morphological changes in the underlying microvessels remains poorly understood. Retinal and cerebral microvessels share morphological and physiological properties. We compared computationally-derived PVS morphologies with retinal vessel morphologies in older people. We analysed data from community-dwelling individuals who underwent multimodal brain MRI and retinal fundus camera imaging at mean age 72.55 years (SD=0.71). We assessed centrum semiovale PVS computationally to determine PVS total volume and count, and mean per-subject individual PVS length, width and size. We analysed retinal images using the VAMPIRE software suite, obtaining the Central Retinal Artery and Vein Equivalents (CRVE and CRAE), Arteriole-to-Venule ratio (AVR), and fractal dimension (FD) of both eyes. We investigated associations using general linear models, adjusted for age, gender, and major vascular risk factors. In 381 subjects with all measures, increasing total PVS volume and count were associated with decreased CRAE in the left eye (volume β=−0.170, count β=−0.184, p<0.001). No associations of PVS with CRVE were found. The PVS total volume, individual width and size increased with decreasing FD of the arterioles (a) and venules (v) of the left eye (total volume: FDa β=−0.137, FDv β=−0.139, p<0.01; width: FDa β=−0.144, FDv β=−0.158, p<0.01; size: FDa β=−0.157, FDv β=−0.162, p<0.01). Increase in PVS number and size visible on MRI reflect arteriolar narrowing and lower retinal arteriole and venule branching complexity, both markers of impaired microvascular health. Computationally-derived PVS metrics may be an early indicator of failing vascular health and should be tested in longitudinal studies.
登录
查看更多内容
影响因子：
4.6
作者：
Ballerini L;Lovreglio R;Valdés Hernández MDC;Ramirez J;MacIntosh BJ;Black SE;Wardlaw JM
通讯作者：
Wardlaw JM
影响因子：
4.1
作者：
Deary IJ;Gow AJ;Taylor MD;Corley J;Brett C;Wilson V;Campbell H;Whalley LJ;Visscher PM;Porteous DJ;Starr JM
通讯作者：
Starr JM
DOI：
10.1136/jnnp-2013-305815
发表时间：
2014-05
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
Hurford R;Charidimou A;Fox Z;Cipolotti L;Jager R;Werring DJ
通讯作者：
Werring DJ
影响因子：
4.2
作者：
Ballerini, Lucia;Booth, Tom;Wardlaw, Joanna
通讯作者：
Wardlaw, Joanna
影响因子：
5.7
作者：
Dubost, Florian;Yilmaz, Pinar;de Bruijne, Marleen
通讯作者：
de Bruijne, Marleen