Cell cycle regulation in Trypanosoma brucei.
Cell cycle regulation in Trypanosoma brucei.
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DOI：
10.1016/j.molbiopara.2007.01.017
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发表时间：
2007-05
影响因子：
1.5
通讯作者：
Hammarton, Tansy C.
中科院分区：
文献类型：
--
作者：
Hammarton, Tansy C.
细胞分裂是由复杂和相互关联的信号转导途径调节的，这些信号转导途径在时间和空间上精确地协调涉及复制和分离细胞组成部分的一系列复杂事件。在布氏锥虫中，近年来在鉴定细胞周期的分子调节剂并阐明其功能方面取得了相当大的进展，尽管许多调节剂无疑仍有待鉴定，并且在确定信号转导途径方面还有很长的路要走。然而，T.布鲁塞在许多方面都不寻常。对锥虫细胞周期调控因子同源基因的分析表明，它们在锥虫体内的功能存在差异，并且在锥虫细胞周期调控因子同源基因中缺失了许多其他关键的调控因子。布鲁塞。细胞周期调控在不同的寄生虫生活史阶段是不同的，T。与模式真核生物相比，布鲁氏菌似乎使用不同的检查点控制策略。因此，T.布氏杆菌已经进化出控制其细胞周期的新途径。
Cell division is regulated by intricate and interconnected signal transduction pathways that precisely coordinate, in time and space, the complex series of events involved in replicating and segregating the component parts of the cell. In Trypanosoma brucei, considerable progress has been made over recent years in identifying molecular regulators of the cell cycle and elucidating their functions, although many regulators undoubtedly remain to be identified, and there is still a long way to go with respect to determining signal transduction pathways. However, it is clear that cell cycle regulation in T. brucei is unusual in many respects. Analyses of trypanosome orthologues of conserved eukaryotic cell cycle regulators have demonstrated divergence of their function in the parasite, and a number of other key regulators are missing from T. brucei. Cell cycle regulation differs in different parasite life cycle stages, and T. brucei appears to use different checkpoint control strategies compared to model eukaryotes. It is therefore probable that T. brucei has evolved novel pathways to control its cell cycle.
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