Estrogen is an important mediator of mast cell activation in ovarian endometriomas.
Estrogen is an important mediator of mast cell activation in ovarian endometriomas.
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雌激素是卵巢子宫内膜异位囊肿肥大细胞激活的重要介质。
DOI：
10.1530/rep-17-0457
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Xinmei Zhang
中科院分区：
文献类型：
--
作者：
Tianhong Zhu;Shaojie Ding;Tiantian Li;Libo Zhu;Xiufeng Huang;Xinmei Zhang
Endometriosis is an estrogen-dependent disease. Previous research has shown that abnormal enzymes associated with estrogen (E2) metabolism and an increased number of mast cells (MCs) in endometriomas are implicated in the pathogenesis of endometriosis. However, it remains unclear how MCs mediate the role of E2 in endometriosis. Accordingly, we investigated whether E2 was associated with the number of MCs, and the rate of degranulation, in local ovarian endometriomas, as well as the role of E2 on MCs during the pathogenesis of endometriosis. Using enzyme-linked immunosorbent assay and immunohistochemistry, we found that concentrations of E2, and the number and activity of MCs, were significantly higher in ovarian endometriomas than in controls, and that these parameters were correlated with the severity of endometriosis-associated dysmenorrhea. By measuring the release of hexosaminidase, we found that the rate of RBL2H3 cell degranulation increased after E2 treatment. Furthermore, activation of RBL2H3 cells by E2 was found to trigger the release of biologically active nerve growth factor, which promotes neurite outgrowth in PC12 cells and also sensitizes dorsal root ganglion cells via upregulation of Nav1.8 and transient receptor potential cation channel (subfamily V member 1) expression levels. When treated with E2, endometriotic cells could promote RBL2H3 cell recruitment by upregulating expression levels of stem cell factor, transforming growth factor-β and monocyte chemoattractant protein-1; these observations were not evident with control endometrial cells. Thus, elevated E2 concentrations may be a key factor for degranulation and recruitment of MCs in ovarian endometriomas, which play a key role in endometriosis-associated dysmenorrhea.
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DOI：
--
发表时间：
2015
期刊：
--
影响因子：
--
作者：
Wenqian Xiong;Ling Zhang;Lan Yu;Wei Xie;Yicun Man;Yao Xiong;Hengwei Liu;Yi Liu
通讯作者：
Wenqian Xiong;Ling Zhang;Lan Yu;Wei Xie;Yicun Man;Yao Xiong;Hengwei Liu;Yi Liu
影响因子：
3.7
作者：
Jensen F;Woudwyk M;Teles A;Woidacki K;Taran F;Costa S;Malfertheiner SF;Zenclussen AC
通讯作者：
Zenclussen AC
DOI：
10.1111/j.8755-8920.2000.440407.x
发表时间：
2000-10
影响因子：
3.6
作者：
Y. Osuga;K. Koga;O. Tsutsumi;T. Igarashi;R. Okagaki;Y. Takai;H. Matsumi;H. Hiroi;T. Fujiwara
通讯作者：
Y. Osuga;K. Koga;O. Tsutsumi;T. Igarashi;R. Okagaki;Y. Takai;H. Matsumi;H. Hiroi;T. Fujiwara
影响因子：
6.7
作者：
K. Zeitoun;S. Bulun
通讯作者：
K. Zeitoun;S. Bulun
DOI：
10.1523/jneurosci.22-23-10277.2002
发表时间：
2002-12
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
Nathaniel T. Blair;B. Bean
通讯作者：
Nathaniel T. Blair;B. Bean