Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation.
Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation.
复制标题
DOI：
10.1371/journal.pone.0014409
复制
发表时间：
2010-12-22
期刊：
影响因子：
3.7
通讯作者：
Zenclussen AC
中科院分区：
文献类型：
--
作者：
Jensen F;Woudwyk M;Teles A;Woidacki K;Taran F;Costa S;Malfertheiner SF;Zenclussen AC
肥大细胞（MC）长期以来一直被怀疑是植入的重要参与者，这是基于它们的脱粒引起关键因子的释放的事实，例如，组胺、MMPs、类胰蛋白酶和VEGF，已知它们参与胚胎附着和后部侵入子宫。此外，MC脱粒与妊娠期间的血管生成相关。子宫中MC的数量已显示在人类月经周期和大鼠和小鼠的发情周期期间波动，表明激素对其从外周到子宫的募集有影响。然而，MC迁移到子宫的机制仍然未知。我们首先利用迁移试验表明，MCs能够迁移到子宫和胎儿-母体界面后，通过激素的变化上调趋化因子受体的表达。通过使用卵巢切除动物模型，我们提供了明确的证据，也在体内，雌二醇和孕酮吸引MC到子宫，并进一步刺激其成熟和脱粒。我们认为雌二醇和孕酮调节MCs从外周向子宫的迁移和脱颗粒，这可能为子宫的着床做好准备。
Mast cells (MCs) have long been suspected as important players for implantation based on the fact that their degranulation causes the release of pivotal factors, e.g., histamine, MMPs, tryptase and VEGF, which are known to be involved in the attachment and posterior invasion of the embryo into the uterus. Moreover, MC degranulation correlates with angiogenesis during pregnancy. The number of MCs in the uterus has been shown to fluctuate during menstrual cycle in human and estrus cycle in rat and mouse indicating a hormonal influence on their recruitment from the periphery to the uterus. However, the mechanisms behind MC migration to the uterus are still unknown. We first utilized migration assays to show that MCs are able to migrate to the uterus and to the fetal-maternal interface upon up-regulation of the expression of chemokine receptors by hormonal changes. By using a model of ovariectomized animals, we provide clear evidences that also in vivo, estradiol and progesterone attract MC to the uterus and further provoke their maturation and degranulation. We propose that estradiol and progesterone modulate the migration of MCs from the periphery to the uterus and their degranulation, which may prepare the uterus for implantation.
登录
查看更多内容
DOI：
10.1111/j.1432-1033.1994.tb18980.x
发表时间：
1994-07-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
LEES, M;TAYLOR, DJ;WOOLLEY, DE
通讯作者：
WOOLLEY, DE
影响因子：
3.8
作者：
Bosquiazzo, V. L.;Ramos, J. G.;Luque, E. H.
通讯作者：
Luque, E. H.
影响因子：
2.2
作者：
Karaca, Turan;Yoruk, Mecit;Uslu, Baris Atalay
通讯作者：
Uslu, Baris Atalay
影响因子：
2.1
作者：
Cohen, Marie;Bischof, Paul
通讯作者：
Bischof, Paul
DOI：
10.1083/jcb.109.2.891
发表时间：
1989-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Fisher SJ;Cui TY;Zhang L;Hartman L;Grahl K;Zhang GY;Tarpey J;Damsky CH
通讯作者：
Damsky CH