Phage-bacterial interactions in the evolution of toxigenic Vibrio cholerae.
Phage-bacterial interactions in the evolution of toxigenic Vibrio cholerae.
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DOI：
10.4161/viru.22351
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发表时间：
2012-11-15
期刊：
影响因子：
5.2
通讯作者：
Mekalanos JJ
中科院分区：
文献类型：
--
作者：
Faruque SM;Mekalanos JJ
了解支持新的病原菌克隆出现的遗传和生态因素对于制定预防措施至关重要。霍乱弧菌是霍乱流行的病原体，代表了这一过程的范例，因为这种生物是通过获得毒力基因从环境非致病菌株进化而来的。霍乱弧菌、霍乱毒素和毒素共调节菌毛的主要毒力因子分别由一个溶源噬菌体(CTxφ)和一个致病岛编码。霍乱弧菌中与CTXφ协同进行基因水平转移的其他噬菌体已经被鉴定，并且存在发现新的噬菌体或遗传元件的潜力，这些新的噬菌体或遗传元件支持环境适应性和毒力基因的转移，从而导致新流行株的出现。噬菌体还被证明在调节季节性霍乱流行方面发挥了关键作用。因此，推动致病性霍乱弧菌进化的一系列复杂的自然现象包括，除其他因素外，参与水平基因转移或有利于霍乱弧菌新克隆出现的杀菌选择过程的噬菌体。
Understanding the genetic and ecological factors which support the emergence of new clones of pathogenic bacteria is vital to develop preventive measures. Vibrio cholerae the causative agent of cholera epidemics represents a paradigm for this process in that this organism evolved from environmental non-pathogenic strains by acquisition of virulence genes. The major virulence factors of V. cholerae, cholera toxin (CT) and toxin coregulated pilus (TCP) are encoded by a lysogenic bacteriophage (CTXφ) and a pathogenicity island, respectively. Additional phages which cooperate with the CTXφ in horizontal transfer of genes in V. cholerae have been characterized, and the potential exists for discovering yet new phages or genetic elements which support the transfer of genes for environmental fitness and virulence leading to the emergence of new epidemic strains. Phages have also been shown to play a crucial role in modulating seasonal cholera epidemics. Thus, the complex array of natural phenomena driving the evolution of pathogenic V. cholerae includes, among other factors, phages that either participate in horizontal gene transfer or in a bactericidal selection process favoring the emergence of new clones of V. cholerae.
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影响因子：
3.2
作者：
Campos, J;Martínez, E;Fando, R
通讯作者：
Fando, R
影响因子：
3.2
作者：
Davis, BM;Moyer, KE;Waldor, MK
通讯作者：
Waldor, MK
影响因子：
2.8
作者：
BHADRA, RK;ROYCHOUDHURY, S;DAS, J
通讯作者：
DAS, J
影响因子：
3.2
作者：
Faruque, SM;Bin Naser, I;Mekalanos, JJ
通讯作者：
Mekalanos, JJ
DOI：
10.1073/pnas.0237385100
发表时间：
2003-02-04
影响因子：
11.1
作者：
Faruque, SM;Kamruzzaman, M;Nair, GB
通讯作者：
Nair, GB