Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss.
Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss.
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DOI：
10.1007/s10571-022-01218-3
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发表时间：
2023-03
影响因子：
4
通讯作者：
中科院分区：
文献类型：
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神经细胞氨基酸代谢异常参与了抑郁症的发生和发展。牛磺酸是大脑发育所需的重要氨基酸。在这里，微透析结合代谢组学分析显示，在大脑内侧前额叶皮层（mPFC）的细胞外液中的牛磺酸水平显着降低慢性社会失败应激（CSDS）诱导的抑郁症小鼠。因此，补充牛磺酸可能是一种有效的干预抑郁症。我们发现，牛磺酸补充剂有效地挽救不动时间在尾部悬挂试验和改善社会回避行为的CSDS小鼠。此外，牛磺酸治疗保护CSDS小鼠免受树突复杂性，棘密度和不同类型棘比例的损害。补充牛磺酸后，这些小鼠的mPFC中N-甲基-d-天冬氨酸受体亚单位2A（一种重要的突触受体）的表达在很大程度上得到恢复。这些结果表明，牛磺酸通过保护皮层神经元免于树突棘丢失和突触蛋白缺陷而发挥抗抑郁作用。在线版本包含补充材料，可通过10.1007/s10571-022-01218-3获得。
Abnormal amino acid metabolism in neural cells is involved in the occurrence and development of major depressive disorder. Taurine is an important amino acid required for brain development. Here, microdialysis combined with metabonomic analysis revealed that the level of taurine in the extracellular fluid of the cerebral medial prefrontal cortex (mPFC) was significantly reduced in mice with chronic social defeat stress (CSDS)-induced depression. Therefore, taurine supplementation may be usable an intervention for depression. We found that taurine supplementation effectively rescued immobility time during a tail suspension assay and improved social avoidance behaviors in CSDS mice. Moreover, taurine treatment protected CSDS mice from impairments in dendritic complexity, spine density, and the proportions of different types of spines. The expression of N-methyl d-aspartate receptor subunit 2A, an important synaptic receptor, was largely restored in the mPFC of these mice after taurine supplementation. These results demonstrated that taurine exerted an antidepressive effect by protecting cortical neurons from dendritic spine loss and synaptic protein deficits. The online version contains supplementary material available at 10.1007/s10571-022-01218-3.
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影响因子：
168.9
作者：
Kupfer, David J.;Frank, Ellen;Phillips, Mary L.
通讯作者：
Phillips, Mary L.
影响因子：
7.5
作者：
Heidari, Reza;Behnamrad, Shima;Vazin, Afsaneh
通讯作者：
Vazin, Afsaneh
DOI：
10.1007/978-3-319-15126-7_43
发表时间：
2015-01-01
期刊：
TAURINE 9
影响因子：
--
作者：
Chan, Christopher Y.;Singh, Inderbir;Banerjee, Shailesh P.
通讯作者：
Banerjee, Shailesh P.
影响因子：
4.4
作者：
Jangra, Ashok;Rajput, Prabha;Lahkar, Mangala
通讯作者：
Lahkar, Mangala
影响因子：
3.7
作者：
Nivison-Smith L;Collin SP;Zhu Y;Ready S;Acosta ML;Hunt DM;Potter IC;Kalloniatis M
通讯作者：
Kalloniatis M