Pathophysiology of Obstructive Sleep Apnea in Aging Women.
Pathophysiology of Obstructive Sleep Apnea in Aging Women.
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DOI：
10.1007/s40675-021-00218-x
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发表时间：
2021-12
影响因子：
1.8
通讯作者：
Mateika JH
中科院分区：
文献类型：
--
作者：
Qiu Q;Mateika JH
以下综述旨在探讨老年女性睡眠呼吸暂停的病理生理学。该综述首先介绍了四种内型（即，更易塌陷的气道、上气道肌肉反应性、唤醒阈值和环路增益），其可能在阻塞性睡眠呼吸暂停的起始中起作用。此后，睡眠呼吸暂停患病率的性别差异被认为是沿着年轻女性和老年女性之间存在的患病率差异。在此讨论之后，我们考虑每种内型如何可能有助于老年妇女睡眠呼吸暂停患病率的增加。最后，我们讨论了如何修改的一种形式的呼吸可塑性，长期促进，这可能有助于减轻年轻女性的呼吸暂停事件可能会修改老年女性阻塞性睡眠呼吸暂停。总体而言，已发表的文献表明，老年女性的睡眠呼吸暂停患病率增加。这种增加主要与更可塌陷的气道有关，并可能与上气道肌肉活动的反应性降低有关。相比之下，环路增益或唤醒阈值的改变似乎与老年女性睡眠呼吸暂停的患病率增加无关。此外，我们认为，长期促进的缓解可能有助于增加老年妇女睡眠呼吸暂停的患病率。
The following review is designed to explore the pathophysiology of sleep apnea in aging women. The review initially introduces four endotypes (i.e., a more collapsible airway, upper airway muscle responsiveness, arousal threshold, and loop gain) that may have a role in the initiation of obstructive sleep apnea. Thereafter, sex differences in the prevalence of sleep apnea are considered along with differences in the prevalence that exist between younger and older women. Following this discussion, we consider how each endotype might contribute to the increase in prevalence of sleep apnea in aging women. Lastly, we address how modifications in one form of respiratory plasticity, long-term facilitation, that might serve to mitigate apneic events in younger women may be modified in aging women with obstructive sleep apnea. Overall, the published literature indicates that the prevalence of sleep apnea is increased in aging women. This increase is linked primarily to a more collapsible airway and possibly to reduced responsiveness of upper airway muscle activity. In contrast, modifications in loop gain or the arousal threshold do not appear to have a role in the increased prevalence of sleep apnea in aging women. Moreover, we suggest that mitigation of long-term facilitation could contribute to the increased prevalence of sleep apnea in aging women.
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影响因子：
3.3
作者：
Gerst, David G., III;Yokhana, Sanar S.;Mateika, Jason H.
通讯作者：
Mateika, Jason H.
影响因子：
3.3
作者：
Kirkness, Jason P.;Schwartz, Alan R.;Patil, Susheel P.
通讯作者：
Patil, Susheel P.
影响因子：
3.3
作者：
Chowdhuri, Susmita;Pranathiageswaran, Sukanya;Badr, M. Safwan
通讯作者：
Badr, M. Safwan
影响因子：
24.3
作者：
Carlisle, Thomas;Carthy, Elliott R.;Morrell, Mary J.
通讯作者：
Morrell, Mary J.
影响因子：
39.2
作者：
GUILLEMINAULT, C;STOOHS, R;CLERK, A
通讯作者：
CLERK, A