Lymphocyte subpopulations of regional lymph nodes in human colon and gastric adenocarcinomas
Lymphocyte subpopulations of regional lymph nodes in human colon and gastric adenocarcinomas
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人结肠癌和胃腺癌区域淋巴结的淋巴细胞亚群
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
F. Gambón
中科院分区：
文献类型：
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作者：
Beatriz Lores;M. PachecoCarracedo;Josefina Oliver;P. Parada;F. Gambón
摘要为了研究宿主对肿瘤的免疫反应，必须了解区域引流淋巴结的细胞组成。 局部淋巴结肿大是结肠癌和胃腺癌的常见表现。我们研究了结肠癌和胃腺癌的正常非反应性淋巴结和区域引流淋巴结的细胞组成。在正常非反应性淋巴结中，T淋巴细胞（CD 2+，CD 7+）构成淋巴网状细胞的最大部分。这些淋巴细胞主要是CD4+，并且表达CD45抗原的CD45RA亚型的细胞多于表达CD45RO的细胞。反应性淋巴结中CD 4 + CD 45 RA+细胞比例降低，B细胞数量增加。虽然反应性淋巴结中的大部分T细胞是CD4+ CD45RO+，但它们的比例与正常非反应性淋巴结中的比例相似。我们研究了参与T和B淋巴细胞相互作用和活化过程的分子CD 28和CD 80的存在。CD28分子在所有T淋巴细胞中均有表达，而CD80分子在B淋巴细胞膜上弱表达。
Abstract In order to study the host immune response to tumours, previous knowledge of the cellular composition of regional draining lymph nodes is necessary. Enlarged regional lymph nodes are a common finding in colon and gastric adenocarcinomas. We have studied the cellular composition of normal non-reactive and of regional draining lymph nodes of colon and gastric adenocarcinomas. In normal non-reactive lymph nodes, T lymphocytes (CD2+, CD7+) constituted the largest fraction of the lymphoreticular cells. These lymphocytes were mainly CD4+, and there were more cells expressing the CD45RA isoform of the CD45 antigen than CD45RO. Reactive lymph nodes presented a decreased proportion of CD4+ CD45RA+ cells and an increased number of B cells. Although most of the T cells in the reactive nodes were CD4+ CD45RO+, their proportion was similar to that found in normal non-reactive nodes. We studied the presence of the molecules CD28 and CD80 involved in the processes of interaction and activation of T and B lymphocytes. The CD28 molecule was found in all the T lymphocytes, while the CD80 molecule was weakly expressed on the B lymphocyte membrane.
DOI：
10.1073/pnas.91.6.2105
发表时间：
1994-03-15
影响因子：
11.1
作者：
CELIS, E;TSAI, V;SERRA, HM
通讯作者：
SERRA, HM
人类 B 细胞活化和粘附的调节。
影响因子：
29.7
作者：
Clark,EA;Lane,PJ
通讯作者：
Lane,PJ