Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study.
Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study.
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DOI：
10.1002/ana.25877
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发表时间：
2020-11
影响因子：
11.2
通讯作者：
Absinta, Martina
中科院分区：
文献类型：
--
作者：
Maggi, Pietro;Sati, Pascal;Nair, Govind;Cortese, Irene C. M.;Jacobson, Steven;Smith, Bryan R.;Nath, Avindra;Ohayon, Joan;van Pesch, Vincent;Perrotta, Gaetano;Pot, Caroline;Theaudin, Marie;Martinelli, Vittorio;Scotti, Roberta;Wu, Tianxia;Du Pasquier, Renaud;Calabresi, Peter A.;Filippi, Massimo;Reich, Daniel S.;Absinta, Martina
在多发性硬化症（MS）中，慢性活动性白色病变的一个子集在MRI上可通过其顺磁性边缘识别，越来越多的证据支持其与临床疾病严重程度的相关性。在这里，我们研究了它们在鉴别诊断中的潜在作用，筛选了438名受不同神经系统疾病（MS，其他炎症，感染性和非炎症）影响的个体的国际多中心临床研究样本。顺磁边缘病变检测，很少发生在其他神经系统疾病（52%的MS与7%的非MS病例），产生了高特异性（93%）区分MS与非MS。未来的前瞻性多中心研究应进一步验证其作为诊断生物标志物的作用。
In multiple sclerosis (MS), a subset of chronic active white matter lesions are identifiable on MRI by their paramagnetic rims, and increasing evidence supports their association with clinical disease severity. Here we study their potential role in differential diagnosis, screening an international multicenter clinical research-based sample of 438 individuals affected by different neurological conditions (MS, other inflammatory, infectious, and non-inflammatory). Paramagnetic rim lesion detection, rarely occurring in other neurological conditions (52% of MS vs 7% of non-MS cases), yielded high specificity (93%) in differentiating MS from non-MS. Future prospective multicenter studies should further validate its role as a diagnostic biomarker.
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影响因子：
--
作者：
Petri, Michelle;Orbai, Ana-Maria;Alarcon, Graciela S.;Gordon, Caroline;Merrill, Joan T.;Fortin, Paul R.;Bruce, Ian N.;Isenberg, David;Wallace, Daniel J.;Nived, Ola;Sturfelt, Gunnar;Ramsey-Goldman, Rosalind;Bae, Sang-Cheol;Hanly, John G.;Sanchez-Guerrero, Jorge;Clarke, Ann;Aranow, Cynthia;Manzi, Susan;Urowitz, Murray;Gladman, Dafna;Kalunian, Kenneth;Costner, Melissa;Werth, Victoria P.;Zoma, Asad;Bernatsky, Sasha;Ruiz-Irastorza, Guillermo;Khamashta, Munther A.;Jacobsen, Soren;Buyon, Jill P.;Maddison, Peter;Dooley, Mary Anne;van vollenhoven, Ronald F.;Ginzler, Ellen;Stoll, Thomas;Peschken, Christine;Jorizzo, Joseph L.;Callen, Jeffrey P.;Lim, S. Sam;Fessler, Barri J.;Inanc, Murat;Kamen, Diane L.;Rahman, Anisur;Steinsson, Kristjan;Franks, Andrew G., Jr.;Sigler, Lisa;Hameed, Suhail;Fang, Hong;Ngoc Pham;Brey, Robin;Weisman, Michael H.;McGwin, Gerald, Jr.;Magder, Laurence S.
通讯作者：
Magder, Laurence S.
影响因子：
12.7
作者：
Luchetti S;Fransen NL;van Eden CG;Ramaglia V;Mason M;Huitinga I
通讯作者：
Huitinga I
影响因子：
11.2
作者：
Absinta, Martina;Nair, Govind;Reich, Daniel S.
通讯作者：
Reich, Daniel S.
影响因子：
5.8
作者：
Manouchehrinia, Ali;Westerlind, Helga;Hillert, Jan
通讯作者：
Hillert, Jan
影响因子：
3.5
作者：
Absinta, M.;Sati, P.;Reich, D. S.
通讯作者：
Reich, D. S.