Antibiotic clearance of Ehrlichia canis from dogs infected by intravenous inoculation of carrier blood.
Antibiotic clearance of Ehrlichia canis from dogs infected by intravenous inoculation of carrier blood.
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DOI：
10.1196/annals.1428.087
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发表时间：
2008-12
影响因子：
5.2
通讯作者：
Stich RW
中科院分区：
文献类型：
--
作者：
Schaefer JJ;Kahn J;Needham GR;Rikihisa Y;Ewing SA;Stich RW
犬埃利希体是犬单核细胞埃利希体病（CME）的病原，是蜱传人畜共患病原体的有用模型，其中许多感染狗。本研究的目的是评估利福平和强力霉素方案清除犬大肠杆菌感染以及减轻CME的效果。小猎犬急性期感染犬E. canis后静脉接种携带者血，给予利福平或强力霉素治疗。血液学值的改善表明两种治疗方法都有效地缓解了疾病的症状。在抗生素治疗后，所有狗的外周血都变为pcr阴性，这表明这些感染已被消除，利福平是治疗CME的有效替代化疗药物。
Ehrlichia canis is the etiologic agent of canine monocytic ehrlichiosis (CME) and is a useful model for tick-borne zoonotic pathogens, many of which infect dogs. The purpose of this study was to evaluate rifampin and doxycycline regimens for clearance of E. canis infections in addition to alleviation of CME. Beagles were infected with E. canis by intravenous inoculation with carrier blood and treated with either rifampin or doxycycline after the acute phase of CME. Improved hematological values demonstrated that both treatments effectively relieved signs of the disease. Peripheral blood from all dogs became PCR-negative after antibiotic treatment, suggesting that these infections were eliminated and that rifampin is an effective alternative chemotherapeutic agent for treatment of CME.
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影响因子：
8
作者：
Krause, PJ;Corrow, CL;Bakken, JS
通讯作者：
Bakken, JS
影响因子：
4.9
作者：
Schaefer, John J.;Needham, Glen R.;Stich, R. W.
通讯作者：
Stich, R. W.
影响因子：
9.4
作者：
Wen, BH;Rikihisa, Y;Bartsch, R
通讯作者：
Bartsch, R
影响因子：
2.6
作者：
Bremer, WG;Schaefer, JJ;Stich, RW
通讯作者：
Stich, RW
影响因子：
2.6
作者：
Stich, R. W.;Schaefer, John J.;Bremer, William G.;Needham, Glen R.;Jittapalapong, Sathaporn
通讯作者：
Jittapalapong, Sathaporn