The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens.
The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens.
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SARS-CoV-2 刺突糖蛋白生物合成、结构、功能和抗原性：对基于刺突的疫苗免疫原设计的影响
DOI：
10.3389/fimmu.2020.576622
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发表时间：
2020
影响因子：
7.3
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Duan L;Zheng Q;Zhang H;Niu Y;Lou Y;Wang H
由严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）正在持续流行，对全球公共卫生构成严重威胁，并给整个人类社会带来严重负担。与其他冠状病毒一样，SARS-CoV-2基因组编码刺突（S）糖蛋白，其从成熟病毒粒子的表面突出。S糖蛋白在病毒附着、融合和进入宿主细胞中发挥着重要作用。S糖蛋白的表面位置使其成为宿主免疫应答的直接靶标，使其成为中和抗体的主要靶标。鉴于其在病毒感染和适应性免疫中的关键作用，S蛋白是大多数疫苗策略以及治疗干预的焦点。本文综述了SARS-CoV-2 S蛋白的生物合成、结构、功能和抗原性等方面的研究进展，旨在为基于S蛋白的疫苗和治疗药物的设计和开发提供有价值的见解。
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public health and imposes a severe burden on the entire human society. Like other coronaviruses, the SARS-CoV-2 genome encodes spike (S) glycoproteins, which protrude from the surface of mature virions. The S glycoprotein plays essential roles in virus attachment, fusion and entry into the host cell. Surface location of the S glycoprotein renders it a direct target for host immune responses, making it the main target of neutralizing antibodies. In the light of its crucial roles in viral infection and adaptive immunity, the S protein is the focus of most vaccine strategies as well as therapeutic interventions. In this review, we highlight and describe the recent progress that has been made in the biosynthesis, structure, function, and antigenicity of the SARS-CoV-2 S glycoprotein, aiming to provide valuable insights into the design and development of the S protein-based vaccines as well as therapeutics.
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