Apparent propagator anisotropy from single-shell diffusion MRI acquisitions.
Apparent propagator anisotropy from single-shell diffusion MRI acquisitions.
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DOI：
10.1002/mrm.28620
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发表时间：
2021-05
影响因子：
3.3
通讯作者：
Jones DK
中科院分区：
文献类型：
--
作者：
Aja-Fernández S;Tristán-Vega A;Jones DK
表观传播子各向异性（阿帕）是一种新的扩散MRI度量，与分数各向异性（FA）相比，它利用了系综平均传播子各向异性（PA）的优势，可以从单壳数据中估计。完整PA的计算需要采集具有多个扩散方向和不同B-值的大型数据集，导致处理时间极长。这阻碍了社区采用PA，尽管有证据表明它提供了FA之外的有意义的信息。假设在给定外壳处的表观测量可以实现类似的灵敏度/特异性，则可以避免计算完整的传播因子。假设扩散各向异性（DiA）不依赖于B-值，则报告了使用单个壳（即B-值）信息的封闭式表达式。健康和患病受试者的公开数据库用于将阿帕与其他各向异性测量进行比较。阿帕提供的结构信息与PA为健康受试者提供的结构信息相关，同时还揭示了两种病理的白色物质区域的统计学相关差异，其可靠性高于FA。此外，阿帕的计算复杂度类似于FA，处理时间比PA低几个数量级。阿帕可以提取更多的相关白色物质的信息比FA，没有任何额外的数据采集的要求。这使得阿帕成为一个有吸引力的选择，用于采用现有的扩散MRI分析管道。
The apparent propagator anisotropy (APA) is a new diffusion MRI metric that, while drawing on the benefits of the ensemble averaged propagator anisotropy (PA) compared to the fractional anisotropy (FA), can be estimated from single‐shell data. Computation of the full PA requires acquisition of large datasets with many diffusion directions and different b‐values, and results in extremely long processing times. This has hindered adoption of the PA by the community, despite evidence that it provides meaningful information beyond the FA. Calculation of the complete propagator can be avoided under the hypothesis that a similar sensitivity/specificity may be achieved from apparent measurements at a given shell. Assuming that diffusion anisotropy (DiA) is nondependent on the b‐value, a closed‐form expression using information from one single shell (ie, b‐value) is reported. Publicly available databases with healthy and diseased subjects are used to compare the APA against other anisotropy measures. The structural information provided by the APA correlates with that provided by the PA for healthy subjects, while it also reveals statistically relevant differences in white matter regions for two pathologies, with a higher reliability than the FA. Additionally, APA has a computational complexity similar to the FA, with processing‐times several orders of magnitude below the PA. The APA can extract more relevant white matter information than the FA, without any additional demands on data acquisition. This makes APA an attractive option for adoption into existing diffusion MRI analysis pipelines.
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