The Role of Pseudomonas aeruginosa Virulence Factors in Cytoskeletal Dysregulation and Lung Barrier Dysfunction.
The Role of Pseudomonas aeruginosa Virulence Factors in Cytoskeletal Dysregulation and Lung Barrier Dysfunction.
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DOI：
10.3390/toxins13110776
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发表时间：
2021-11-02
期刊：
影响因子：
4.2
通讯作者：
Che P
中科院分区：
文献类型：
--
作者：
Wagener BM;Hu R;Wu S;Pittet JF;Ding Q;Che P
假单胞菌（P.）铜绿假单胞菌是一种机会性病原体，在免疫功能低下的患者中引起严重感染和医院获得性肺炎。铜绿假单胞菌占所有医院获得性肺炎病例的20%，归因死亡率约为30- 40%。铜绿假单胞菌诱导的肺炎的临床结果不佳归因于其破坏肺屏障完整性的能力，导致肺水肿和菌血症的发展。气道上皮细胞和内皮细胞是保护肺免受入侵病原体的重要结构块。铜绿假单胞菌产生许多毒力因子，这些毒力因子可以通过利用真核细胞中的细胞骨架网络和细胞间连接复合物来直接或间接地调节屏障功能。本文综述了铜绿假单胞菌毒力因子及其对细胞骨架网络和相关组分的调节作用，以及调节气道上皮和内皮细胞屏障功能的分子机制。更好地了解这些过程将有助于为针对铜绿假单胞菌引起的肺炎的新治疗方法奠定基础。
Pseudomonas (P.) aeruginosa is an opportunistic pathogen that causes serious infections and hospital-acquired pneumonia in immunocompromised patients. P. aeruginosa accounts for up to 20% of all cases of hospital-acquired pneumonia, with an attributable mortality rate of ~30–40%. The poor clinical outcome of P. aeruginosa-induced pneumonia is ascribed to its ability to disrupt lung barrier integrity, leading to the development of lung edema and bacteremia. Airway epithelial and endothelial cells are important architecture blocks that protect the lung from invading pathogens. P. aeruginosa produces a number of virulence factors that can modulate barrier function, directly or indirectly, through exploiting cytoskeleton networks and intercellular junctional complexes in eukaryotic cells. This review summarizes the current knowledge on P. aeruginosa virulence factors, their effects on the regulation of the cytoskeletal network and associated components, and molecular mechanisms regulating barrier function in airway epithelial and endothelial cells. A better understanding of these processes will help to lay the foundation for new therapeutic approaches against P. aeruginosa-induced pneumonia.
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影响因子：
11.8
作者：
Belardi B;Hamkins-Indik T;Harris AR;Kim J;Xu K;Fletcher DA
通讯作者：
Fletcher DA
影响因子：
6.7
作者：
Bucior I;Pielage JF;Engel JN
通讯作者：
Engel JN
影响因子：
4.8
作者：
Belyy, Alexander;Santecchia, Ignacio;Mechold, Undine
通讯作者：
Mechold, Undine
影响因子：
2.8
作者：
Belyy, Alexander;Mechold, Undine;Ladant, Daniel
通讯作者：
Ladant, Daniel
DOI：
10.1096/fj.201902915r
发表时间：
2020-02
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Che P;Wagener BM;Zhao X;Brandon AP;Evans CA;Cai GQ;Zhao R;Xu ZX;Han X;Pittet JF;Ding Q
通讯作者：
Ding Q