Circadian rhythm of prohormone atrial natriuretic peptides 1-30, 31-67 and 99-126 in man.-猫眼课题宝

人体激素原心房钠尿肽 1-30、31-67 和 99-126 的昼夜节律。

DOI：

10.3109/07420528809067785

发表时间：

1988

期刊：

Chronobiology international

影响因子：

2.8

通讯作者：

中科院分区：

医学4区

文献类型：

作者：

C. Winters;A. Sallman;D. Vesely

由心房钠尿因子（ANF原）N端氨基酸1-30和31-67组成的两种肽，在体外舒张主动脉，在体内降低血压，并具有与心房钠尿因子（ANF，激素原99-126氨基酸）相似的利尿钠特性。最近发现pro ANF 1-30和pro ANF 31-67以及ANF在人体中循环。为了确定这三种肽激素的循环血浆浓度是否存在昼夜节律变化，我们对 8 名住院工作人员志愿者住院 24 小时的一天进行了研究。这5名男性和3名女性，年龄介乎25至39岁，于次日0800、1200、1600、2000、0000、0400及0800抽取血液样本。这些内部官员中有一半整夜未眠，而另一半则从午夜至 0800 点睡觉，并以仰卧姿势抽取 0400 份血浆样本。对于仰卧和直立受试者，所有三种肽激素的峰值水平均为 0400。结论是，正常、活跃的人这三种肽激素存在昼夜节律，无论姿势如何，其峰值水平都在0400。

Two peptides consisting of amino acids 1-30 and 31-67 of the N-terminal end of the prohormone of the atrial natriuretic factor (pro ANF), vasodilate aortas in vitro, lower blood pressure in vivo, and have natriuretic properties similar to the atrial natriuretic factor (ANF, amino acids 99-126 of the prohormone). It has been recently discovered that pro ANF 1-30 and pro ANF 31-67 as well as ANF circulate in man. To determine if these three peptide hormones have a circadian variation in their circulating plasma concentrations, eight housestaff volunteers were studied on a day when they were in the hospital for 24 hr. These 5 men and 3 women, ages 25 to 39 had blood samples taken at 0800, 1200, 1600, 2000, 0000, 0400 and 0800 on the following day. One-half of these house officers were up all night while the other half went to sleep from midnight to 0800 and had their 0400 plasma samples drawn while in a supine position. The peak level for all three peptide hormones was at 0400 for both supine and upright subjects. It was concluded that there are circadian rhythms in normal, active people of these three peptide hormones, whose peak levels are at 0400 irrespective of posture.

Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle.